Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab−/− mice
Belz, Gabrielle T. and Liu, Haiyan and Andreansky, Samita and Doherty, Peter C. and Stevenson, Philip G.,, 84, 337-341 (2003),
doi = https://doi.org/10.1099/vir.0.18821-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= The murine gammaherpesvirus-68 kills I-Ab−/− mice despite the presence of virus-specific CD8+ cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-Ab−/− mice and I-Ab+/+ controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.,
language=,
type=