Hepatitis C virus RNA replication is resistant to tumour necrosis factor-α
Frese, Michael and Barth, Kerstin and Kaul, Artur and Lohmann, Volker and Schwärzle, Verena and Bartenschlager, Ralf,, 84, 1253-1259 (2003),
doi = https://doi.org/10.1099/vir.0.18997-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= It was demonstrated using self-replicating hepatitis C virus (HCV) RNAs that both types of interferons (IFNs) (in particular IFN-α and IFN-γ) are potent inhibitors of HCV replication in Huh-7 cells. Because IFN-γ and tumour necrosis factor (TNF)-α trigger a partially overlapping set of antiviral defence mechanisms, it is tempting to speculate that TNF-α also inhibits HCV replication. However, this study shows that TNF-α does not affect HCV protein and RNA synthesis, nor does it synergistically enhance the inhibitory effect of IFN-γ. Taken together, these results demonstrate that HCV replication in Huh-7 cells is highly resistant to TNF-α. It is, therefore, unlikely that the increased production of TNF-α, which is seen in many hepatitis C patients, contributes to HCV clearance by inducing antiviral defence mechanisms in infected hepatocytes.,
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