1887

Abstract

Lumpy skin disease virus (LSDV), a capripoxvirus with a host range limited to ruminants, was evaluated as a replication-deficient vaccine vector for use in non-ruminant hosts. By using the rabies virus glycoprotein (RG) as a model antigen, it was demonstrated that recombinant LSDV encoding the rabies glycoprotein (rLSDV-RG) was able to express RG in both permissive (ruminant) and non-permissive (non-ruminant) cells. The recombinant LSDV, however, replicated to maturity only in permissive but not in non-permissive cells. Recombinant LSDV-RG was assessed for its ability to generate immunity against RG in non-ruminant hosts (rabbits and mice). Rabbits inoculated with rLSDV-RG produced rabies virus (RV) neutralizing antibodies at levels twofold higher than those reported by the WHO to be protective. BALB/c mice immunized with rLSDV-RG elicited levels of RV-specific cellular immunity (T-cell proliferation) comparable with those of mice immunized with a commercial inactivated rabies vaccine (Verorab; Pasteur Merieux). Most importantly, mice immunized with rLSDV-RG were protected from an aggressive intracranial rabies virus challenge.

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2003-08-01
2024-03-29
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References

  1. Alexander R. A., Plowright W., Haig D. A. 1957; Cytopathic agents associated with LSD of cattle. Bull Epizoot Dis Africa 5:489–492
    [Google Scholar]
  2. Allen T., Vogel T., Fuller D. 11 other authors 2000; Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen. J Immunol 164:4968–4978
    [Google Scholar]
  3. Amara R., Villinger F., Staprans S. 10 other authors 2002; Different patterns of immune responses but similar control of a simian–human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines. J Virol 76:7625–7631
    [Google Scholar]
  4. Antoine G., Scheiflinger F., Dorner F., Falkner F. G. 1998; The complete genomic sequence of the MVA strain: comparison with other orthopoxviruses. Virology 244:365–396
    [Google Scholar]
  5. Aspden K. 2002; A study of the host-restricted lumpy skin disease virus as a vaccine vector using rabies virus as a model . PhD Thesis University of Cape Town, South Africa;
  6. Aspden K., van Dijk A. A., Bingham J., Cox D., Passmore J., Williamson A.-L. 2002; Immunogenicity of a recombinant lumpy skin disease virus (Neethling vaccine strain) expressing the rabies virus glycoprotein in cattle. Vaccine 20:2693–2701
    [Google Scholar]
  7. Barouche D. H., Santra S., Kuroda M. J. 13 other authors 2001; Reduction of simian–human immunodeficiency virus 89.6P viraemia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination. J Virol 75:5151–5158
    [Google Scholar]
  8. Baxby D., Paoletti E. 1992; Potential use of non-replicating vectors as recombinant vaccines. Vaccine 10:8–9
    [Google Scholar]
  9. Belshe R. B., Stevens C., Gorse G. J. 20 other authors 2001; Safety and immunogenicity of a canarypox-vectored HIV-1 vaccine with or without gp120: a phase 2 study in higher- and lower-risk volunteers. J Infect Dis 183:1343–1352
    [Google Scholar]
  10. Bender B. S., Rowe C. A., Taylor F., Wyatt L. S., Moss B., Small P. A. 1996; Oral immunization with a replication-deficient recombinant vaccinia virus protects mice against influenza. J Virol 70:6418–6424
    [Google Scholar]
  11. Boyle D. B., Coupar B. E. H. 1988; A dominant selectable marker for the construction of recombinant poxviruses. Gene 65:123–128
    [Google Scholar]
  12. Cadoz M., Strady A., Meignier B., Taylor J., Tartaglia J., Paoletti E., Plotkin S. 1992; Immunisation with canarypox virus expressing rabies glycoprotein. Lancet 339:1429–1449
    [Google Scholar]
  13. Carroll M. W., Overwijk W., Surman D., Tsung K., Moss B., Restifo M. 1998; Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, IL-12, and a model tumour antigen. J Natl Cancer Inst 90:1881–1887
    [Google Scholar]
  14. Cliquet F., Aubert M., Sagne L. 1998; Development of F1 antibody virus neutralization test (FAVN) for the quantitation of rabies virus neutralizing antibodies. J Immunol Methods 212:79–89
    [Google Scholar]
  15. Cohen A., Cox D., van Dijk A. A., Korber A., Dumbell K. R., Williamson A.-L. 1997; Lumpy skin disease virus as a vaccine vector for rift valley fever virus and bovine ephemeral fever virus. In Proceedings of the 4th Congress of the European Society for Veterinary Virology Edinburgh, UK: 24–17 August pp  230–231
    [Google Scholar]
  16. Dean D. J., Abelseth M. K., Atanasiu P. 1996; The fluorescent antibody test. In Laboratory Techniques in Rabies , 4th edn. pp  88–95 Edited by Meslin F.-X., Kaplan M. M., Koprowski H. Geneva: World Health Organization;
    [Google Scholar]
  17. Dutta J. K., Pradhan S. C., Dutta T. K. 1992; Rabies antibody titres in vacinees: protection, failure and prospects. Int J Clin Pharmacol Ther Toxicol 30:107–112
    [Google Scholar]
  18. Gupta K., Hudgens M., Corey L. 14 other authors 2002; Safety and immunogenicity of a high-titred canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS vaccine evaluation group protocol 022A. J Acquir Immune Defic Syndr 29:254–261
    [Google Scholar]
  19. Hirsch V. M., Fuerst T. R., Sutter G. 9 other authors 1996; Patterns of viral replication correlate with outcome in SIV-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. J Virol 70:3741–3752
    [Google Scholar]
  20. Horig H., Lee D., Conkright W. 10 other authors 2000; Phase I clinical trial of a recombinant canarypoxvirus (ALVAC) vaccine expressing human carcinoembryonic antigen and the B7.1 co-stimulatory molecule. Cancer Immunol Immunother 49:504–514
    [Google Scholar]
  21. MacGregor G. R., Caskey C. T. 1989; Construction of plasmids that express E . coli β -galactosidase in mammalian cells. Nucleic Acids Res 7:2365
    [Google Scholar]
  22. MacGregor G. R., Nolan G. P., Fiering S., Roederer H., Herzenberg L. A. 1991; Use of E. coli lacZ ( β-galactosidase) as a reporter gene. Methods Mol Biol 7:217–235
    [Google Scholar]
  23. Mayr A., Danner K. 1978; Vaccination against pox diseases under immunosuppressive conditions. Dev Biol Stand 41:225–234
    [Google Scholar]
  24. Men R., Wyatt L., Tokimatsu I., Arakaki S., Shameem G., Elkins R., Chanock R., Moss B., Lai C. 2000; Immunization of rhesus monkeys with a recombinant of modified vaccinia virus Ankara expressing a truncated envelope glycoprotein of dengue type 2 virus induced resistance to dengue type 2-virus challenge. Vaccine 18:3113–3122
    [Google Scholar]
  25. Merchlinsky M., Moss B. 1992; Introduction of foreign DNA into the VV genome by in vitro ligation: recombinant-independent selectable cloning vectors. Virology 190:522–526
    [Google Scholar]
  26. Meyer H., Sutter G., Mayr A. 1991; Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence. J Gen Virol 72:1031–1038
    [Google Scholar]
  27. Mifune K., Takeuchi E., Napiorkowski P. A., Yamada A., Sakamoto K. 1981; Essential role of T-cells in the post-exposure prophylaxis of rabies in mice. Microbiol Immunol 25:895–904
    [Google Scholar]
  28. Moss B. 1996; Genetically engineered poxviruses for recombinant gene expression, variation, and safety. Proc Natl Acad Sci U S A 93:11341–11348
    [Google Scholar]
  29. Moss B. 2001; Poxviridae : the viruses and and their replication. In Virology , 4th edn. pp  2849–2883 Edited by Knipe D. M., Howley P. M. Philidelphia: Lippincott Williams and Wilkins;
    [Google Scholar]
  30. Moss B., Carroll M. W., Wyatt L. S. 11 other authors 1996; Host range restricted non-replicating vaccinia virus vectors as vaccine candidates. Adv Exp Med Biol 397:7–13
    [Google Scholar]
  31. Paoletti E. 1996; Applications of poxvirus vectors to vaccination: an update. Proc Natl Acad Sci U S A 93:11349–11353
    [Google Scholar]
  32. Perkus M., Piccini A., Lipinskas B., Paoletti E. 1985; Recombinant vaccinia virus: immunization against multiple pathogens. Science 229:981–984
    [Google Scholar]
  33. Prozesky L., Barnard B. J. H. 1982; A study of the pathology of lumpy skin disease in cattle. Onderstepoort J Vet Res 49:167–175
    [Google Scholar]
  34. Redfield R. R., Wright D. C., James W. D., Jones T. S., Brown C., Burke D. C. 1987; Disseminated vaccinia in military recruit with human immunodeficiency virus (HIV) disease. N Engl J Med 316:673–676
    [Google Scholar]
  35. Rodriguez D., Rodriquez J. R., Rodriguez J. F., Trauber D., Esteban M. 1989; Highly attenuated vaccinia virus mutants for the generation of safe recombinant viruses. Proc Natl Acad Sci U S A 86:1287–1291
    [Google Scholar]
  36. Romero C. H., Barret T., Evans S. A., Kitching R. P., Gershan P. D., Bostock C., Black D. N. 1993; Single capripox recombinant vaccine for the protection of cattle against rinderpest and lumpy skin disease. Vaccine 11:737–742
    [Google Scholar]
  37. Romero C. H., Barrett T., Chamberlain R. W., Kitching P., Flemming M., Black D. N. 1994a; Recombinant capripoxvirus expressing the hemagglutinin protein gene of rinderpest virus: protection of cattle against rinderpest and lumpy skin disease virus. Virology 204:425–429
    [Google Scholar]
  38. Romero C. H., Barrett T., Kitching R. P., Carn V. M., Black D. N. 1994b; Protection of cattle against rinderpest and lumpy skin disease with a recombinant capripoxvirus expressing the fusion protein gene of rinderpest virus. Vet Rec 135:154–154
    [Google Scholar]
  39. Seligmann E. B. J. 1973; The NIH test for potency. In Laboratory Techniques in Rabies , 3rd edn. pp  229–286 Edited by Kapman M. M., Koprowski H. Geneva: World Health Organization;
    [Google Scholar]
  40. Smith G., Moss B. 1983; Infectious poxvirus vectors have capacity for at least 25 000 base pairs of foreign DNA. Gene 25:21–28
    [Google Scholar]
  41. Somogyi P., Frazier J., Skinner M. A. 1993; Fowlpox virus host range restriction: gene expression, DNA replication, and morphogenesis in non-permissive mammalian cells. Virology 197:439–444
    [Google Scholar]
  42. Stannard L. M., Marais D., Kow D., Dumbell K. 1998; Evidence for incomplete replication of penguin poxvirus in cells of mammalian origin. J Gen Virol 79:1637–1646
    [Google Scholar]
  43. Stittelaar K., Kuiken T., de Swart R. 8 other authors 2001; Safety of MVA in immune-suppressed macaques. Vaccine 19:3700–3709
    [Google Scholar]
  44. Sutter G., Wyatt L. S., Foley P. L., Bennink J. R., Moss B. 1994; A recombinant vector derived from the host range-restricted and highly attenuated MVA strain of vaccinia virus stimulates protective immunity in mice to influenza virus. Vaccine 12:1032–1040
    [Google Scholar]
  45. Taylor J., Weinberg R., Languet B., Desmettre P., Paoletti E. 1988; Recombinant fowlpox virus inducing protective immunity in non-avian species. Vaccine 6:497–503
    [Google Scholar]
  46. Taylor J., Trimarchi C., Weinberg R., Languet B., Guillemin F., Desmettre P., Paoletti E. 1991; Efficacy studies on a canarypox–rabies recombinant virus. Vaccine 9:190–193
    [Google Scholar]
  47. Tulman E., Afonso C., Lu Z., Zsak L., Kutish G., Rock D. 2001; Genome of LSDV. J Virol 75:7122–7130
    [Google Scholar]
  48. Tulman E. R., Afonso C., Lu Z. 7 other authors 2002; The genomes of sheeppox and goatpox viruses. J Virol 76:6054–6061
    [Google Scholar]
  49. Weiss K. E. 1968; Lumpy skin disease virus. Virol Monogr 3:111–130
    [Google Scholar]
  50. Welter J., Taylor J., Tartaglia J., Paoletti E., Stephenson C. 2000; Vaccination against canine distemper virus infection in infant ferrets with and without maternal antibody protection, using recombinant attenuated poxvirus vaccines. J Virol 74:6358–6367
    [Google Scholar]
  51. Willey R., Byrum R., Piatak M. 8 other authors 2003; Control of viremia and prevention of SHIV-induced disease in rhesus macaques immunized with recombinant VV plus inactivated SIV and HIV-1 particles. J Virol 77:1163–1174
    [Google Scholar]
  52. WHO (World Health Organization) 1980 The Global Eradication of Smallpox . Final Report of the Global Commission for the Certification of Smallpox Eradication . History of International Public Health, no . 4 Geneva: World Health Organization;
    [Google Scholar]
  53. Wyatt L. S., Shors S. T., Murphy B. R., Moss B. 1996; Development of a replication-deficient recombinant vaccinia virus vaccine effective against parainfluenza virus 3 infection in an animal model. Vaccine 14:1451–1458
    [Google Scholar]
  54. Wyatt L. S., Carroll M. W., Czerny C. P., Merchlinsky M., Sisler J. R., Moss B. 1998; Marker rescue of the host range restriction defects of modified vaccinia virus Ankara. Virology 251:334–342
    [Google Scholar]
  55. Xiang Z. Q., Knowles B. B., McCarrick J. W., Ertl H. C. 1995; Immune effector mechanisms required for protection to rabies virus. Virology 214:398–404
    [Google Scholar]
  56. Young E., Basson P. A., Weiss K. E. 1970; Experimental infection of game animals with lumpy skin disease virus (prototype strain Neethling). Onderstepoort J Vet Res 32:79–88
    [Google Scholar]
  57. Zavala F., Rodrigues M., Rodriguez D., Rodriguez J., Nussenzweig R., Esteban M. 2001; A striking property of recombinant poxviruses: efficient inducers of in vivo expansion of primed CD8+ T cells. Virology 280:155–159
    [Google Scholar]
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