In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity
Magiorkinis, Gkikas and Paraskevis, Dimitrios and Vandamme, Anne-Mieke and Magiorkinis, Emmanouil and Sypsa, Vana and Hatzakis, Angelos,, 84, 2715-2722 (2003),
doi = https://doi.org/10.1099/vir.0.19180-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Recombination plays a pivotal role in the evolutionary process of many different virus species, including retroviruses. Analysis of all human immunodeficiency virus type 1 (HIV-1) intersubtype recombinants revealed that they are more complex than described initially. Recombination frequency is higher within certain genomic regions, such as partial reverse transcriptase (RT), vif/vpr, the first exons of tat/rev, vpu and gp41. A direct correlation was observed between recombination frequency and sequence similarity across the HIV-1 genome, indicating that sufficient sequence similarity is required upstream of the recombination breakpoint. This finding suggests that recombination in vivo may occur preferentially during reverse transcription through the strand displacement-assimilation model rather than the copy-choice model.,
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