Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein–Barr virus Katzman, Rebecca B. and Longnecker, Richard,, 84, 2987-2992 (2003), doi = https://doi.org/10.1099/vir.0.19252-0, publicationName = Microbiology Society, issn = 0022-1317, abstract= Epstein–Barr virus (EBV) infection is a multi-step process, first requiring virus binding to the host cell, followed by fusion of the viral envelope with the host cell plasma membrane. Efficient EBV entry into B cells requires, at the minimum, the interaction of the EBV-encoded glycoproteins gp350 with cellular CD21 and gp42 with MHC class II proteins. In this study, use of the cholesterol-binding drugs methyl-β-cyclodextrin and nystatin efficiently inhibited EBV infection of target Burkitt's lymphoma B-cell lines, indicating an important role for cholesterol and suggesting the involvement of lipid rafts in EBV infection., language=, type=