RT Journal Article SR Electronic(1) A1 Stokes, H. L. A1 Easton, A. J. A1 Marriott, A. C.YR 2003 T1 Chimeric pneumovirus nucleocapsid (N) proteins allow identification of amino acids essential for the function of the respiratory syncytial virus N protein JF Journal of General Virology, VO 84 IS 10 SP 2679 OP 2683 DO https://doi.org/10.1099/vir.0.19370-0 PB Microbiology Society, SN 1465-2099, AB The nucleocapsid (N) protein of the pneumovirus respiratory syncytial virus (RSV) is a major structural protein which encapsidates the RNA genome and is essential for replication and transcription of the RSV genome. The N protein of the related virus pneumonia virus of mice (PVM) is functionally unable to replace the RSV N protein in a minigenome replication assay. Using chimeric proteins, in which the immediate C-terminal part of the RSV N protein was replaced with the equivalent region of the PVM N protein, it was shown that six amino acid residues near the C terminus of the N protein (between residues 352–369) are essential for its function in replication and for the ability of the N protein to bind to the viral phosphoprotein, P., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.19370-0