1887

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Volume 85, Issue 1

Poxvirus genomes: a phylogenetic analysis Free

Abstract

The evolutionary relationships of 26 sequenced members of the poxvirus family have been investigated by comparing their genome organization and gene content and by using DNA and protein sequences for phylogenetic analyses. The central region of the genome of chordopoxviruses (ChPVs) is highly conserved in gene content and arrangement, except for some gene inversions in (FPV) and species-specific gene insertions in FPV and (MCV). In the central region 90 genes are conserved in all ChPVs, but no gene from near the termini is conserved throughout the subfamily. Inclusion of two entomopoxvirus (EnPV) sequences reduces the number of conserved genes to 49. The EnPVs are divergent from ChPVs and between themselves. Relationships between ChPV genera were evaluated by comparing the genome size, number of unique genes, gene arrangement and phylogenetic analyses of protein sequences. Overall, genus is the most divergent. The next most divergent ChPV genus is , whose sole member, MCV, infects only man. The , , and genera cluster together, with and sharing a common ancestor, and are distinct from the genus (OPV). Within the OPV genus, , and strain Brighton Red (BR) do not group closely with any other OPV, and form a subgroup, and is most closely related to CPV-GRI-90. This suggests that CPV-BR and GRI-90 should be separate species.

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  • Accepted:
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2004-01-01
2024-04-16
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Poxvirus genomes: a phylogenetic analysis
J. Gen. Virol. 85, 105 (2004); https://doi.org/10.1099/vir.0.19565-0
/content/journal/jgv/10.1099/vir.0.19565-0
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