The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14–I31) is dispensable for the virus in vitro

References

1. Bleiber G., Munoz M., Ciuffi A., Meylan P., Telenti A. 2001; Individual contribution of protease and reverse transcriptase to infectivity, replication and protein maturation of antiretroviral drug resistant human immunodeficiency virus type 1. J Virol 75:3291–3300
   [Google Scholar]
2. Chen C., Li F., Montelaro R. C. 2001; Functional roles of equine infectious anemia virus Gag p9 in viral budding and infection. J Virol 75:9762–9770
   [Google Scholar]
3. Demirov D. G., Orenstein J. M., Freed E. O. 2002; The late domain of human immunodeficiency virus type 1 p6 promotes virus release in a cell type-dependent manner. J Virol 76:105–117
   [Google Scholar]
4. Dettenhofer M., Yu X. F. 1999; Proline residues in human immunodeficiency virus type 1 p6^Gag exert a cell type-dependent effect on viral replication and virion incorporation of Pol proteins. J Virol 73:4696–4704
   [Google Scholar]
5. Garnier L., Ratner L., Rovinski B., Cao S.-X., Wills J. W. 1998; Particle size determinants in the human immunodeficiency virus type 1 Gag protein. J Virol 72:4667–4677
   [Google Scholar]
6. Garrus J. E., von Schwedler U. K., Pornillos O. W. 9 other authors 2001; Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell 107:55–65
   [Google Scholar]
7. Göttlinger H. G., Dorfman T., Sodroski J. G., Haseltine W. A. 1991; Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release. Proc Natl Acad Sci U S A 88:3195–3199
   [Google Scholar]
8. Hou D., Cenciarelli C., Jensen J. P., Nguygen H. B., Weissman A. M. 1994; Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines. J Biol Chem 269:14244–14247
   [Google Scholar]
9. Huang M., Orenstein J. M., Martin M. A., Freed E. O. 1995; p6^Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease. J Virol 69:6810–6818
   [Google Scholar]
10. Kondo E., Göttlinger H. G. 1996; A conserved LXXLF sequence is the major determinant in p6 ^gag required for the incorporation of human immunodeficiency virus type 1 Vpr. J Virol 70:159–164
    [Google Scholar]
11. Louis J. M., Clore G. M., Gronenborn A. M. 1999; Autoprocessing of HIV-1 protease is tightly coupled to protein folding. Nat Struct Biol 6:868–875
    [Google Scholar]
12. Lu Y. L., Bennett R. P., Wills J. W., Gorelick R., Ratner L. 1995; A leucine triplet repeat sequence (LXX)4 in p6 ^gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles. J Virol 69:6873–6879
    [Google Scholar]
13. Martin-Serrano J., Zang T., Bieniasz P. D. 2001; HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress. Nat Med 7:1313–1319
    [Google Scholar]
14. Muller B., Patschinsky T., Krausslich H. G. 2002; The late-domain-containing protein p6 is the predominant phosphoprotein of human immunodeficiency virus type 1 particles. J Virol 76:1015–1024
    [Google Scholar]
15. Ott D. E., Coren L. V., Copeland T. D. 7 other authors 1998; Uquitin is covalently attached to the p6^Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12^Gag protein of Moloney murine leukemia virus. J Virol 72:2962–2968
    [Google Scholar]
16. Ott D. E., Chertova E. N., Busch L. K., Gagliardi T. D., Johnson D. G. 1999; Mutational analysis of the hydrophobic tail of the human immunodeficiency virus type 1 p6^Gag protein produces a mutant that fails to package its envelope protein. J Virol 73:19–28
    [Google Scholar]
17. Ott D. E., Coren L. V., Chertova E. N., Gagliardi T. D., Schubert U. 2000; Ubiquitination of HIV-1 and MuLV Gag. Virology 278:111–121
    [Google Scholar]
18. Partin K., Zybarth G., Ehrlich L., DeCrombrugghe M., Wimmer E., Carter C. 1991; Deletion of sequences upstream of the proteinase improves the proteolytic processing of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A 88:4776–4780
    [Google Scholar]
19. Paulus C., Hellebrand S., Tessmer U., Wolf H., Kräusslich H.-G., Wagner R. 1999; Competitive inhibition of human immunodeficiency virus type-1 protease by the Gag–Pol transframe protein. J Biol Chem 274:21539–21543
    [Google Scholar]
20. Peters S., Munoz M., Yerly S. 8 other authors 2001; Resistance to nucleoside analog reverse transcriptase inhibitors mediated by human immunodeficiency virus type 1 p6 protein. J Virol 75:9644–9653
    [Google Scholar]
21. Schubert U., Ott D. E., Chertova E. N., Welker R., Tessmer U., Princiotta M. F., Bennink J. R., Krausslich H. G., Yewdell J. W. 2000; Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2. Proc Natl Acad Sci U S A 97:13057–13062
    [Google Scholar]
22. VerPlank L., Bouamr F., LaGrassa T. J., Agresta B., Kikonyogo A., Leis J., Carter C. A. 2001; Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55^Gag . Proc Natl Acad Sci U S A 98:7724–7729
    [Google Scholar]
23. Vogt V. M. 2000; Ubiquitin in retrovirus assembly: actor or bystander?. Proc Natl Acad Sci U S A 97:12945–12947
    [Google Scholar]
24. Yu X.-F., Matsuda Z., Yu Q.-C., Lee T.-H., Essex M. 1995; Role of the C terminus Gag protein in human immunodeficiency virus type 1 virion assembly and maturation. J Gen Virol 76:3171–3179
    [Google Scholar]
25. Yu X.-F., Dawson L., Tian C.-J., Flexner C., Dettenhofer M. 1998; Mutations of the human immunodeficiency virus type 1 p6^Gag domain results in reduced retention of Pol proteins during virus assembly. J Virol 72:3412–3417
    [Google Scholar]