%0 Journal Article %A Simmonds, Peter %A Douglas, Jill %A Bestetti, Giovanna %A Longhi, Erika %A Antinori, Spinello %A Parravicini, Carlo %A Corbellino, Mario %T A third genotype of the human parvovirus PARV4 in sub-Saharan Africa %D 2008 %J Journal of General Virology, %V 89 %N 9 %P 2299-2302 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.2008/001180-0 %I Microbiology Society, %X PARV4 is a recently discovered human parvovirus widely distributed in injecting drug users in the USA and Europe, particularly in those co-infected with human immunodeficiency virus (HIV). Like parvovirus B19, PARV4 persists in previously exposed individuals. In bone marrow and lymphoid tissue, PARV4 sequences were detected in two sub-Saharan African study subjects with AIDS but without a reported history of parenteral exposure and who were uninfected with hepatitis C virus. PARV4 variants infecting these subjects were phylogenetically distinct from genotypes 1 and 2 (formerly PARV5) that were reported previously. Analysis of near-complete genome sequences demonstrated that they should be classified as a third (equidistant) PARV4 genotype. The availability of a further near-complete genome sequence of this novel genotype facilitated identification of conserved novel open reading frames embedded in the ORF2 coding sequence; one encoded a putative protein with identifiable homology to SAT proteins of members of the genus Parvovirus. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.2008/001180-0