RT Journal Article SR Electronic(1) A1 Simmonds, Peter A1 Douglas, Jill A1 Bestetti, Giovanna A1 Longhi, Erika A1 Antinori, Spinello A1 Parravicini, Carlo A1 Corbellino, MarioYR 2008 T1 A third genotype of the human parvovirus PARV4 in sub-Saharan Africa JF Journal of General Virology, VO 89 IS 9 SP 2299 OP 2302 DO https://doi.org/10.1099/vir.0.2008/001180-0 PB Microbiology Society, SN 1465-2099, AB PARV4 is a recently discovered human parvovirus widely distributed in injecting drug users in the USA and Europe, particularly in those co-infected with human immunodeficiency virus (HIV). Like parvovirus B19, PARV4 persists in previously exposed individuals. In bone marrow and lymphoid tissue, PARV4 sequences were detected in two sub-Saharan African study subjects with AIDS but without a reported history of parenteral exposure and who were uninfected with hepatitis C virus. PARV4 variants infecting these subjects were phylogenetically distinct from genotypes 1 and 2 (formerly PARV5) that were reported previously. Analysis of near-complete genome sequences demonstrated that they should be classified as a third (equidistant) PARV4 genotype. The availability of a further near-complete genome sequence of this novel genotype facilitated identification of conserved novel open reading frames embedded in the ORF2 coding sequence; one encoded a putative protein with identifiable homology to SAT proteins of members of the genus Parvovirus., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.2008/001180-0