1887

Abstract

Expression of enhanced green fluorescent protein (EGFP) under control of the promoter-enhancer of chicken infectious anemia virus (CAV) is increased in an oestrogen receptor-enhanced cell line when treated with oestrogen and the promoter-enhancer binds unidentified proteins that recognize a consensus oestrogen response element (ERE). Co-transfection assays with the CAV promoter and the nuclear receptor chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1) showed that expression of EGFP was decreased by 50 to 60 % in DF-1 and LMH cells. The CAV promoter that included sequences at and downstream of the transcription start point had less expression than a short promoter construct. Mutation of a putative E box at this site restored expression levels. Electromobility shift assays showed that the transcription regulator delta-EF1 (EF1) binds to this E box region. These findings indicate that the CAV promoter activity can be affected directly or indirectly by COUP-TF1 and EF1.

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2008-12-01
2024-03-29
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References

  1. Adair B. M. 2000; Immunopathogenesis of chicken anemia virus infection. Dev Comp Immunol 24:247–255 [CrossRef]
    [Google Scholar]
  2. Akai J., Storey K. 2003; Brain or brawn: how FGF signaling gives us both. Cell 115:510–512 [CrossRef]
    [Google Scholar]
  3. Aumais J. P., Lee H. S., DeGannes C., Horsford J., White J. H. 1996; Function of directly repeated half-sites as response elements for steroid hormone receptors. J Biol Chem 271:12568–12577 [CrossRef]
    [Google Scholar]
  4. Berrodin T. J., Marks M. S., Ozato K., Linney E., Lazar M. A. 1992; Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. Mol Endocrinol 6:1468–1478
    [Google Scholar]
  5. Cardona C., Lucio B., O'Connell P., Jagne J., Schat K. A. 2000a; Humoral immune responses to chicken infectious anemia virus in three strains of chickens in a closed flock. Avian Dis 44:661–667 [CrossRef]
    [Google Scholar]
  6. Cardona C. J., Oswald W. B., Schat K. A. 2000b; Distribution of chicken anaemia virus in the reproductive tissues of specific-pathogen-free chickens. J Gen Virol 81:2067–2075
    [Google Scholar]
  7. Carlberg C. 1993; RXR-independent action of the receptors for thyroid hormone, retinoid acid and vitamin D on inverted palindromes. Biochem Biophys Res Commun 195:1345–1353 [CrossRef]
    [Google Scholar]
  8. Chamberlain E. M., Sanders M. M. 1999; Identification of the novel player δ EF1 in estrogen transcriptional cascades. Mol Cell Biol 19:3600–3606
    [Google Scholar]
  9. Comijn J., Berx G., Vermassen P., Verschueren K., van Grunsven L., Bruyneel E., Mareel M., Huylebroeck D., van Roy F. 2001; The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 7:1267–1278 [CrossRef]
    [Google Scholar]
  10. Cooney A. J., Tsai S. Y., O'Malley B. W., Tsai M. J. 1991; Chicken ovalbumin upstream promoter transcription factor binds to a negative regulatory region in the human immunodeficiency virus type 1 long terminal repeat. J Virol 65:2853–2860
    [Google Scholar]
  11. Cooney A. J., Tsai S. Y., O'Malley B. W., Tsai M. J. 1992; Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol Cell Biol 12:4153–4163
    [Google Scholar]
  12. Cooney A. J., Leng X., Tsai S. Y., O'Malley B. W., Tsai M. J. 1993; Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. J Biol Chem 268:4152–4160
    [Google Scholar]
  13. Dillner N. B., Sanders M. M. 2002a; Upstream stimulatory factor (USF) is recruited into a steroid hormone-triggered regulatory circuit by the estrogen-inducible transcription factor δ EF1. J Biol Chem 277:33890–33894 [CrossRef]
    [Google Scholar]
  14. Dillner N. B., Sanders M. M. 2002b; The zinc finger/homeodomain protein δ EF1 mediates estrogen-specific induction of the ovalbumin gene. Mol Cell Endocrinol 192:85–91 [CrossRef]
    [Google Scholar]
  15. Driscoll M. D., Sathya G., Muyan M., Klinge C. M., Hilf R., Bambara R. A. 1998; Sequence requirements for estrogen receptor binding to estrogen response elements. J Biol Chem 273:29321–29330 [CrossRef]
    [Google Scholar]
  16. Forman B. M., Samuels H. H. 1991; pEXPRESS: a family of expression vectors containing a single transcription unit active in prokaryotes, eukaryotes and in vitro . Gene 105:9–15 [CrossRef]
    [Google Scholar]
  17. Furusawa T., Moribe H., Kondoh H., Higashi Y. 1999; Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor δ EF1. Mol Cell Biol 19:8581–8590
    [Google Scholar]
  18. Hallenbeck P. L., Marks M. S., Lippoldt R. E., Ozato K., Nikodem V. M. 1992; Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR β ) enhances DNA binding and TH-dependent transcriptional activation. Proc Natl Acad Sci U S A 89:5572–5576 [CrossRef]
    [Google Scholar]
  19. Jeurissen S. H., Wagenaar F., Pol J. M., van der Eb A. J., Noteborn M. H. 1992; Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and of cell lines after in vitro infection. J Virol 66:7383–7388
    [Google Scholar]
  20. Kato S., Sasaki H., Suzawa M., Masushige S., Tora L., Chambon P., Gronemeyer H. 1995; Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors. Mol Cell Biol 15:5858–5867
    [Google Scholar]
  21. Klinge C. M., Bodenner D. L., Desai D., Niles R. M., Traish A. M. 1997; Binding of type II nuclear receptors and estrogen receptor to full and half-site estrogen response elements in vitro . Nucleic Acids Res 25:1903–1912 [CrossRef]
    [Google Scholar]
  22. Kraus R. J., Perrigoue J. G., Mertz J. E. 2003; ZEB negatively regulates the lytic-switch BZLF1 gene promoter of Epstein–Barr virus. J Virol 77:199–207 [CrossRef]
    [Google Scholar]
  23. Krieg S. A., Krieg A. J., Shapiro D. J. 2001; A unique downstream estrogen responsive unit mediates estrogen induction of proteinase inhibitor-9, a cellular inhibitor of IL-1 β -converting enzyme (caspase 1).. Mol Endocrinol 15:1971–1982
    [Google Scholar]
  24. Markowski-Grimsrud C. J., Schat K. A. 2003; Infection with chicken anemia virus impairs the generation of pathogen-specific cytotoxic T lymphocytes. Immunology 109:283–294 [CrossRef]
    [Google Scholar]
  25. McConnell C. D., Adair B. M., McNulty M. S. 1993; Effects of chicken anemia virus on cell-mediated immune function in chickens exposed to the virus by a natural route. Avian Dis 37:366–374 [CrossRef]
    [Google Scholar]
  26. Miller M. M., Oswald W. B., Scarlet J., Schat K. A. 2001; Patterns of chicken infectious anemia virus (CIAV) seroconversion in three Cornell SPF flocks. In Proceedings of the Second International Symposium on Infectious Bursal Disease and Chicken Infectious Anaemia pp 410–417 Rauischholzhausen, Germany: Institut fur Geflugelkrankheiten, Justus Liebig University; Giessen, Germany:
    [Google Scholar]
  27. Miller M. M., Ealey K. A., Oswald W. B., Schat K. A. 2003; Detection of chicken anemia virus DNA in embryonal tissues and eggshell membranes. Avian Dis 47:662–671 [CrossRef]
    [Google Scholar]
  28. Miller M. M., Jarosinski K. J., Schat K. A. 2005; Positive and negative regulation of chicken anemia virus transcription. J Virol 79:2859–2868 [CrossRef]
    [Google Scholar]
  29. Miyoshi A., Kitajima Y., Sumi K., Sato K., Hagiwara A., Koga Y., Miyazaki K. 2004; Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer 90:1265–1273 [CrossRef]
    [Google Scholar]
  30. Noteborn M. H., Todd D., Verschueren C. A., de Gauw H. W., Curran W. L., Veldkamp S., Douglas A. J., McNulty M. S., van der Eb A. J., Koch G. 1994a; A single chicken anemia virus protein induces apoptosis. J Virol 68:346–351
    [Google Scholar]
  31. Noteborn M. H., Verschueren C. A., Zantema A., Koch G., van der Eb A. J. 1994b; Identification of the promoter region of chicken anemia virus (CAV) containing a novel enhancer-like element. Gene 150:313–318 [CrossRef]
    [Google Scholar]
  32. Noteborn M. H., Verschueren C. A., van Ormondt H., van der Eb A. J. 1998; Chicken anemia virus strains with a mutated enhancer/promoter region share reduced virus spread and cytopathogenicity. Gene 223:165–172 [CrossRef]
    [Google Scholar]
  33. Park J. I., Tsai S. Y., Tsai M. J. 2003; Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions. Keio J Med 52:174–181 [CrossRef]
    [Google Scholar]
  34. Phenix K. V., Meehan B. M., Todd D., McNulty M. S. 1994; Transcriptional analysis and genome expression of chicken anaemia virus. J Gen Virol 75:905–909 [CrossRef]
    [Google Scholar]
  35. Postigo A. A. 2003; Opposing functions of ZEB proteins in the regulation of the TGF β /BMP signaling pathway. EMBO J 22:2443–2452 [CrossRef]
    [Google Scholar]
  36. Postigo A. A., Dean D. C. 1997; ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation. EMBO J 16:3935–3943 [CrossRef]
    [Google Scholar]
  37. Postigo A. A., Dean D. C. 1999; ZEB represses transcription through interaction with the corepressor CtBP. Proc Natl Acad Sci U S A 96:6683–6688 [CrossRef]
    [Google Scholar]
  38. Postigo A. A., Sheppard A. M., Mucenski M. L., Dean D. C. 1997; c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB. EMBO J 16:3924–3934 [CrossRef]
    [Google Scholar]
  39. Postigo A. A., Ward E., Skeath J. B., Dean D. C. 1999; zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesis. Mol Cell Biol 19:7255–7263
    [Google Scholar]
  40. Pringle C. R. 1999; Virus taxonomy at the XIth International congress of Virology. Sydney, Australia: 1999 Arch Virol 144:2065–2069 [CrossRef]
    [Google Scholar]
  41. Quack M., Frank C., Carlberg C. 2002; Differential nuclear receptor signalling from DR4-type response elements. J Cell Biochem 86:601–612 [CrossRef]
    [Google Scholar]
  42. Schat K. A. 2003; Chicken Infectious Anemia. In Diseases of Poultry , 11th edn. pp 182–196Edited by Saif Y. M., Barnes H. J., Fadly A. M., Glisson J. R., McDougald L. R., Swayne D. E. Ames, IA: Blackwell Publishing;
    [Google Scholar]
  43. Sekido R., Murai K., Funahashi J., Kamachi Y., Fujisawa-Sehara A., Nabeshima Y., Kondoh H. 1994; The delta-crystallin enhancer-binding protein δ EF1 is a repressor of E2-box-mediated gene activation. Mol Cell Biol 14:5692–5700 [CrossRef]
    [Google Scholar]
  44. van Grunsven L. A., Schellens A., Huylebroeck D., Verschueren K. 2001; SIP1 (Smad interacting protein 1) and δ EF1 (delta-crystallin enhancer binding factor) are structurally similar transcriptional repressors. J Bone Joint Surg Am 83-A (Suppl 1:S40–S47
    [Google Scholar]
  45. Yuasa N. 1992; Effect of chemicals on the infectivity of chicken anaemia virus. Avian Pathol 21:315–319 [CrossRef]
    [Google Scholar]
  46. Yuasa N., Taniguchi T., Goda M., Shibatani M., Imada T., Hihara H. 1983; Isolation of chicken anemia agent with MDCC-MSB1 cells from chickens in the field. Natl Inst Anim Health Q (Tokyo) 23:75–77
    [Google Scholar]
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