1887

Abstract

Cutaneous human papillomavirus (HPV) has been widely detected in healthy skin. Previous studies have found that UV radiation can activate several HPV types, and a possible role for cutaneous HPV in the development of non-melanoma skin cancer has been suggested. This study investigated the prevalence and type-spectrum of cutaneous HPV in relation to UV radiation by studying forehead skin swab samples from 50 healthy males frequently exposed to the sun and 50 healthy males who were not frequently exposed to the sun. A questionnaire including ethnic background of the participants, history of cancers and a self-assessment of sun-exposure was also conducted and analysed. PCR with the FAP primer pair was carried out to detect HPV DNA in samples. HPV prevalence was higher in individuals who spent more time outdoors and in individuals with a history of skin cancers (=0.044 and =0.04, respectively). Furthermore, individuals wearing sunglasses as a means of sun protection had a lower prevalence of HPV (=0.018). Interestingly, HPV-76 was only detected in the group without frequent sun-exposure (=0.001). These results suggest that increased UV radiation exposure may be a factor leading to a difference in prevalence of cutaneous HPV types.

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2008-11-01
2024-03-29
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References

  1. Akgül B., Lemme W., García-Escudero R., Storey A., Pfister H. J. 2005; UV-B irradiation stimulates the promoter activity of the high-risk, cutaneous human papillomavirus 5 and 8 in primary keratinocytes. Arch Virol 150:145–151 [CrossRef]
    [Google Scholar]
  2. Al Moustafa A. E., Foulkes W. D., Benlimame N., Wong A., Yen L., Bergeron J., Batist G., Alpert L., Alaoui-Jamali M. A. 2004; E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal oral epithelial cells. Oncogene 23:350–358 [CrossRef]
    [Google Scholar]
  3. Alotaibi L., Provost N., Gagnon S., Franco E. L., Coutlee F. 2006; Diversity of cutaneous human papillomavirus types in individuals with and without skin lesion. J Clin Virol 36:133–140 [CrossRef]
    [Google Scholar]
  4. Altschul S. F., Madden T. L., Schaffer A. A., Zhang J., Zhang Z., Miller W., Lipman D. J. 1997; Gapped blast and psi-blast: a new generation of protein database search programs. Nucleic Acids Res 25:3389–3402 [CrossRef]
    [Google Scholar]
  5. Antonsson A., Forslund O., Ekberg H., Sterner G., Hansson B. G. 2000; The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses. J Virol 74:11636–11641 [CrossRef]
    [Google Scholar]
  6. Antonsson A., Erfurt C., Hazard K., Holmgren V., Simon M., Kataoka A., Hossain S., Hakangard C., Hansson B. G. 2003a; Prevalence and type spectrum of human papillomaviruses in healthy skin samples collected in three continents. J Gen Virol 84:1881–1886 [CrossRef]
    [Google Scholar]
  7. Antonsson A., Karanfilovska S., Lindqvist P. G., Hansson B. G. 2003b; General acquisition of human papillomavirus infections of skin occurs in early infancy. J Clin Microbiol 41:2509–2514 [CrossRef]
    [Google Scholar]
  8. Astori G., Lavergne D., Benton C., Hockmayr B., Egawa K., Garbe C., de Villiers E.-M. 1998; Human papillomaviruses are commonly found in normal skin of immunocompetent hosts. J Invest Dermatol 110:752–755 [CrossRef]
    [Google Scholar]
  9. Bell E., Sher S., Hull B., Merrill C., Rosen S., Chamson A., Asselineau D., Dubertret L., Coulomb B. other authors 1983; The reconstitution of living skin. J Invest Dermatol 81:2s–10s [CrossRef]
    [Google Scholar]
  10. Boxman I. L. A., Mulder L. H. C., Vermeer B. J., Bavinck J. N. B., ter Schegget J., Ponec M. 2000; HPV-DNA is not detectable in outgrowing cells from explant cultures of skin lesions established at the air–liquid-interface. J Med Virol 61:281–288 [CrossRef]
    [Google Scholar]
  11. Caroleo M. C., Frasca D., Nistica G., Doria G. 1992; Melatonin as immunomodulator in immunodeficient mice. Immunopharmacology 23:81–89 [CrossRef]
    [Google Scholar]
  12. Dang C., Koehler A., Forschner T., Sehr P., Michael K., Pawlita M., Stockfleth E., Nindl I. 2006; E6/E7 expression of human papillomavirus types in cutaneous squamous cell dysplasia and carcinoma in immunosuppressed organ transplant recipients. Br J Dermatol 155:129–136 [CrossRef]
    [Google Scholar]
  13. Denis P., Nordmann J. P., Elena P. P., Dussaillant M. 1993; Physiological roles of dopamine and neuropeptides in the retina. Fundam Clin Pharmacol 7:293–304 [CrossRef]
    [Google Scholar]
  14. Deragon J.-M., Sinnett D., Mitchell G., Potier M., Labuda D. 1990; Use of γ irradiation to eliminate DNA contamination for PCR. Nucleic Acids Res 18:6149 [CrossRef]
    [Google Scholar]
  15. Dillon J. 1991; New trends in photobiology: the photophysics and photobiology of the eye. J Photochem Photobiol B 10:23–40 [CrossRef]
    [Google Scholar]
  16. Dummer R., Maier T. 2002; UV protection and skin cancer. Recent Results Cancer Res 160:7–12
    [Google Scholar]
  17. Forslund O., Antonsson A., Nordin P., Stenquist B., Goran Hansson B. 1999; A broad range of human papillomavirus types detected with a general PCR method suitable for analysis of cutaneous tumours and normal skin. J Gen Virol 80:2437–2443
    [Google Scholar]
  18. Forslund O., Ly H., Reid C., Higgins G. 2003; A broad spectrum of human papillomavirus types is present in the skin of Australian patients with non-melanoma skin cancers and solar keratosis. Br J Dermatol 149:64–73 [CrossRef]
    [Google Scholar]
  19. Forslund O., Lindelof B., Hradil E., Nordin P., Stenquist B., Kirnbauer R., Slupetzky K., Dillner J. 2004; High prevalence of cutaneous human papillomavirus DNA on the top of skin tumors but not in “stripped” biopsies from the same tumors. J Invest Dermatol 123:388–394 [CrossRef]
    [Google Scholar]
  20. Forslund O., Iftner T., Andersson K., Lindelöf B., Hradil E., Nordin P., Stenquist B., Kirnbauer R., Dillner J., de Villiers E.-M. 2007; Cutaneous human papillomaviruses found in sun-exposed skin: Beta-papillomavirus species 2 predominates in squamous cell carcinoma. J Infect Dis 196:876–883 [CrossRef]
    [Google Scholar]
  21. Frost C. A., Green A. C. 1994; Epidemiology of solar keratoses. Br J Dermatol 131:455–464
    [Google Scholar]
  22. Harwood C. A., Surentheran T., Sasieni P., Proby C. M., Bordea C., Leigh I. M., Wojnarowska F., Breuer J., McGregor J. M. 2004; Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin. Br J Dermatol 150:949–957 [CrossRef]
    [Google Scholar]
  23. Hazard K., Karlsson A., Andersson K., Ekberg H., Dillner J., Forslund O. 2006; Cutaneous human papillomaviruses persist on healthy skin. J Invest Dermatol 127:116–119
    [Google Scholar]
  24. Jankovic B. D. 1994; Neuroimmunomodulation from phenomenology to molecular evidence. Ann N Y Acad Sci 741:1–38
    [Google Scholar]
  25. Kripke M. L. 1988; Immunoregulation of carcinogenesis: past, present, and future. J Natl Cancer Inst 80:722–727 [CrossRef]
    [Google Scholar]
  26. Maestroni G. J. M. 1993; The immunoneuroendocrine role of melatonin. J Pineal Res 14:1–10 [CrossRef]
    [Google Scholar]
  27. Maestroni G. J., Conti A. 1991; Anti-stress role of the melatonin-immuno-opioid network: evidence for a physiological mechanism involving T cell derived, immunoreactive β -endorphin and MET-enkephalin binding to thymic opioid receptors. Int J Neurosci 61:289–298 [CrossRef]
    [Google Scholar]
  28. Massimi P., Thomas M., Bouvard V., Ruberto I., Campo M. S., Tommasino M., Banks L. 2008; Comparative transforming potential of different human papillomaviruses associated with non-melanoma skin cancer. Virology 371:374–379 [CrossRef]
    [Google Scholar]
  29. Michel A., Kopp-Schneider A., Zentgraf H., Gruber A. D., de Villiers E.-M. 2006; E6/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice. J Virol 80:11153–11164 [CrossRef]
    [Google Scholar]
  30. Moore R. Y., Klein D. C. 1974; Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity. Brain Res 71:17–33 [CrossRef]
    [Google Scholar]
  31. Morison W. L. 1989; Effects of ultraviolet radiation on the immune system in humans. Photochem Photobiol 50:515–524 [CrossRef]
    [Google Scholar]
  32. Neugut A. I., Kizelnik-Freilich S., Ackerman C. 1994; Black–white differences in risk for cutaneous, ocular, and visceral melanomas. Am J Public Health 84:1828–1829 [CrossRef]
    [Google Scholar]
  33. Noonan F. P., De Fabo E. C. 1992; Immunosuppression by ultraviolet B radiation: initiation by urocanic acid. Immunol Today 13:250–254 [CrossRef]
    [Google Scholar]
  34. Pamphilon D. H., Alnaqdy A. A., Wallington T. B. 1991; Immunomodulation by ultraviolet light: clinical studies and biological effects. Immunol Today 12:119–123 [CrossRef]
    [Google Scholar]
  35. Parrish J. A., Kripke M. L., Morrison W. L. 1983 Photoimmunology New York: Plenum;
    [Google Scholar]
  36. Pfister H. 2003; Human papillomavirus and skin cancer. J Natl Cancer Inst Monogr 31:52–56
    [Google Scholar]
  37. Purdie K. J., Sexton C. J., Proby C. M., Glover M. T., Williams A. T., Stables J. N., Leigh I. M. 1993; Malignant transformation of cutaneous lesions in renal allograft patients: a role for human papillomavirus?. Cancer Res 53:5328–5333
    [Google Scholar]
  38. Purdie K. J., Pennington J., Proby C. M., Khalaf S., de Villiers E.-M., Leigh I. M., Storey A. 1999; The promoter of a novel human papillomavirus (HPV77) associated with skin cancer displays UV responsiveness, which is mediated through a consensus p53 binding sequence. EMBO J 18:5359–5369 [CrossRef]
    [Google Scholar]
  39. Regnier M., Prunieras M., Woodley D. 1981; Growth of adult human epithelial cells on dermal substrate. In Epidermal Keratinocyte Differentiation and FibrillogenesisFrontiers in Matrix Biology vol. 9 pp 4–35Edited by Prunieras M. Basel: S. Karger;
    [Google Scholar]
  40. Roberts J. E. 1995; Visible light induced changes in the immune response through an eye–brain mechanism (photoneuroimmunology).. J Photochem Photobiol B 29:3–15 [CrossRef]
    [Google Scholar]
  41. Ruhland A., de Villiers E.-M. 2001; Opposite regulation of the HPV 20-URR and HPV 27-URR promoters by ultraviolet irradiation and cytokines. Int J Cancer 91:828–834 [CrossRef]
    [Google Scholar]
  42. Storey A., Thomas M., Kalita A., Harwood C., Gardiol D., Mantovani F., Breuer J., Leigh I. M., Matlashewski G., Banks L. 1998; Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer. Nature 393:229–234 [CrossRef]
    [Google Scholar]
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