Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection
Jacobs, Nathalie and Bartlett, Nathan W. and Clark, Richard H. and Smith, Geoffrey L.,, 89, 2877-2881 (2008),
doi = https://doi.org/10.1099/vir.0.2008/004119-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= The vaccinia virus (VACV) N1 protein is an intracellular virulence factor that has a Bcl-2-like structure and inhibits both apoptosis and signalling from the interleukin 1 receptor, leading to nuclear factor kappa B activation. Here, we investigated the immune response to intranasal infection with a virus lacking the N1L gene (vΔN1L) compared with control viruses expressing N1L. Data presented show that deletion of N1L did not affect the proportion of CD4+ and CD8+ T cells infiltrating the lungs or the cytotoxic T-cell activity of these cells. However, vΔN1L induced an increased local natural killer cell activity between days 4 and 6 post-infection. In addition, in the absence of N1 the host inflammatory infiltrate was characterized by a reduced proportion of lymphocytes bearing the early activation marker CD69. Notably, there was a good correlation between the level of CD69 expression and weight loss. The implications of these findings are discussed.,
language=,
type=