RT Journal Article SR Electronic(1) A1 Nga, Phan Thi A1 Parquet, Maria del Carmen A1 Cuong, Vuong Duc A1 Ma, Shao-Ping A1 Hasebe, Futoshi A1 Inoue, Shingo A1 Makino, Yoshihiro A1 Takagi, Masahiro A1 Nam, Vu Sinh A1 Morita, KouichiYR 2004 T1 Shift in Japanese encephalitis virus (JEV) genotype circulating in northern Vietnam: implications for frequent introductions of JEV from Southeast Asia to East Asia JF Journal of General Virology, VO 85 IS 6 SP 1625 OP 1631 DO https://doi.org/10.1099/vir.0.79797-0 PB Microbiology Society, SN 1465-2099, AB This study analyses the evolutionary relatedness of 16 Japanese encephalitis virus (JEV) isolates (nine from Vietnam and seven from Japan) to previously published JEV strains using E gene sequence data. Vietnamese and Japanese strains isolated between 1986 and 1990 were found to cluster in genotype 3. However, more recent Vietnamese and Japanese strains isolated between 1995 and 2002 grouped within genotype 1, now a dominant though previously unreported genotype in Vietnam. In addition, in this study, strains isolated between 1995 and 2002 were more closely related to those isolated in the 1990s than to the older genotype 1 strains. Recently, the introduction of JEV genotype 1 into Japan and Korea has also been reported. Hence this genotype shift phenomenon may be occurring throughout all East Asia. Further studies on JEV ecology are needed to clarify the mechanism of JEV genotype 1 spread to new territories., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.79797-0