%0 Journal Article %A Poenisch, Marion %A Unterstab, Gunhild %A Wolff, Thorsten %A Staeheli, Peter %A Schneider, Urs %T The X protein of Borna disease virus regulates viral polymerase activity through interaction with the P protein %D 2004 %J Journal of General Virology, %V 85 %N 7 %P 1895-1898 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.80002-0 %I Microbiology Society, %X Borna disease virus polymerase activity is negatively regulated by the viral X protein. Using a virus minireplicon system it was found that all X mutants that no longer interacted with the viral P protein failed to exhibit significant inhibitory activity. The action of X could further be neutralized by expression of a P fragment that contained the X interaction domain but lacked all domains known to mediate interaction with other viral proteins. X thus appears to regulate the activity of the Borna disease virus polymerase by targeting the polymerase cofactor P. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80002-0