RT Journal Article SR Electronic(1) A1 Venter, Marietjie A1 Smit, Sheilagh B. A1 Leman, Patricia A1 Swanepoel, RobertYR 2004 T1 Phylogenetic evidence of widespread distribution of genotype 3 JC virus in Africa and identification of a type 7 isolate in an African AIDS patient JF Journal of General Virology, VO 85 IS 8 SP 2215 OP 2219 DO https://doi.org/10.1099/vir.0.80027-0 PB Microbiology Society, SN 1465-2099, AB JC virus (JCV) is the cause of progressive multifocal leukoencephalophathy (PML) in immunocompromised patients. The paucity of reports from Africa has led to the hypothesis that PML is rare because of an absence of virus genotypes associated with the condition. Genotypes 3 and 6 have been identified in East and West Africa but the distribution of types across the rest of Africa is unknown. Full-length sequences of five JCV cerebrospinal fluid samples from PML patients in South Africa are reported here. Three isolates from African AIDS patients grouped with type 3A or 3B, and one with type 7, while one from a Caucasian leukaemia patient grouped with type 2D. Widespread distribution of type 3 on the continent may reflect migration patterns in antiquity, but this is the first report of type 7 in an African individual. Type 2D has only been isolated previously in South Asia, although transmission of this genotype to Europeans who later settled in South Africa is not unlikely., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80027-0