1887

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Volume 85, Issue 8

A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication Free

Abstract

Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. Two intervening heptad repeat (HR) sequences were found in the C-terminal half of all herpesvirus gBs analysed. A synthetic peptide derived from the HR region (aa 477–510) of bovine herpesvirus type 1 (BoHV-1) gB was studied for its ability to inhibit virus replication. The peptide interfered with cell-to-cell spread and consistently inhibited replication of BoHV-1, with a 50 % effective concentration value (EC) of 5 μM. Inhibition of replication was obtained not only with herpesviruses including pseudorabies virus and herpes simplex virus type 1 but also partly with Newcastle disease virus. Possible mechanisms of membrane fusion inhibition by the peptide are discussed.

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2004-08-01
2024-04-20
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A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication
J. Gen. Virol. 85, 2131 (2004); https://doi.org/10.1099/vir.0.80051-0
/content/journal/jgv/10.1099/vir.0.80051-0
/content/journal/jgv/10.1099/vir.0.80051-0
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