1887

Abstract

A survey for the presence of simian foamy retroviruses (SFVs) was performed in 44 wild-caught apes and monkeys, including 27 gorillas, 11 mandrills and six drills, originating from south Cameroon or Gabon. Combined serological and/or nested-PCR assays indicated SFV infection among five , seven and two . Sequences of a 425 bp fragment of the gene were obtained for 11 animals. Phylogenetic studies indicated that strains from gorillas, mandrills and drills each formed a highly supported phylogenetic clade with, moreover, the existence of two different gorilla SFVs. This study demonstrates for the first time that these animals are naturally infected with specific SFVs. In the context of simian-to-human interspecies transmission, the results confirm that such viruses can also infect humans, as the SFVs identified in wild-caught animals were the same as those recently reported as infecting hunters living in the same geographical areas.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.80241-0
2004-11-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jgv/85/11/vir853313.html?itemId=/content/journal/jgv/10.1099/vir.0.80241-0&mimeType=html&fmt=ahah

References

  1. Bieniasz P. D., Rethwilm A., Pitman R., Daniel M. D., Chrystie I., McClure M. O. 1995; A comparative study of higher primate foamy viruses, including a new virus from a gorilla. Virology 207:217–228 [CrossRef]
    [Google Scholar]
  2. Blewett E. L., Black D. H., Lerche N. W., White G., Eberle R. 2000; Simian foamy virus infections in a baboon breeding colony. Virology 278:183–193 [CrossRef]
    [Google Scholar]
  3. Brooks J. I., Rud E. W., Pilon R. G., Smith J. M., Switzer W. M., Sandstrom P. A. 2002; Cross-species retroviral transmission from macaques to human beings. Lancet 360:387–388 [CrossRef]
    [Google Scholar]
  4. Broussard S. R., Comuzzie A. G., Leighton K. L., Leland M. M., Whitehead E. M., Allan J. S. 1997; Characterization of new simian foamy viruses from African nonhuman primates. Virology 237:349–359 [CrossRef]
    [Google Scholar]
  5. Courgnaud V., Van Dooren S., Liegeois F. 7 other authors 2004; Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys ( Cercocebus agilis ). J Virol 78:4700–4709 [CrossRef]
    [Google Scholar]
  6. Georges-Courbot M. C., Moisson P., Leroy E. 9 other authors 1996; Occurrence and frequency of transmission of naturally occurring simian retroviral infections (SIV, STLV, and SRV) at the CIRMF Primate Center, Gabon. J Med Primatol 25:313–326 [CrossRef]
    [Google Scholar]
  7. Hahn B. H., Shaw G. M., De Cock K. M., Sharp P. M. 2000; AIDS as a zoonosis: scientific and public health implications. Science 287:607–614 [CrossRef]
    [Google Scholar]
  8. Heneine W., Switzer W. M., Sandstrom P. 9 other authors 1998; Identification of a human population infected with simian foamy viruses. Nat Med 4:403–407 [CrossRef]
    [Google Scholar]
  9. Hussain A. I., Shanmugam V., Bhullar V. B. 9 other authors 2003; Screening for simian foamy virus infection by using a combined antigen Western blot assay: evidence for a wide distribution among Old World primates and identification of four new divergent viruses. Virology 309:248–257 [CrossRef]
    [Google Scholar]
  10. Lacoste V., Mauclere P., Dubreuil G., Lewis J., Georges-Courbot M. C., Gessain A. 2000; KSHV-like herpesviruses in chimps and gorillas. Nature 407:151–152 [CrossRef]
    [Google Scholar]
  11. Lacoste V., Mauclere P., Dubreuil G., Lewis J., Georges-Courbot M. C., Gessain A. 2001; A novel gamma 2-herpesvirus of the rhadinovirus 2 lineage in chimpanzees. Genome Res 11:1511–1519 [CrossRef]
    [Google Scholar]
  12. Leendertz F. H., Junglen S., Boesch C., Formenty P., Couacy-Hymann E., Courgnaud V., Pauli G., Ellerbrok H. 2004; High variety of different simian T-cell leukemia virus type 1 strains in chimpanzees ( Pan troglodytes verus ) of the Tai National Park, Cote d'Ivoire. J Virol 78:4352–4356 [CrossRef]
    [Google Scholar]
  13. McClure M. O., Bieniasz P. D., Schulz T. F. 7 other authors 1994; Isolation of a new foamy retrovirus from orangutans. J Virol 68:7124–7130
    [Google Scholar]
  14. Meertens L., Gessain A. 2003; Divergent simian T-cell lymphotropic virus type 3 (STLV-3) in wild-caught Papio hamadryas papio from Senegal: widespread distribution of STLV-3 in Africa. J Virol 77:782–789 [CrossRef]
    [Google Scholar]
  15. Meertens L., Rigoulet J., Mauclere P. 8 other authors 2001; Molecular and phylogenetic analyses of 16 novel simian T cell leukemia virus type 1 from Africa: close relationship of STLV-1 from Allenopithecus nigroviridis to HTLV-1 subtype B strains. Virology 287:275–285 [CrossRef]
    [Google Scholar]
  16. Nerrienet E., Meertens L., Kfutwah A., Foupouapouognigni Y., Gessain A. 2001; Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilis . J Gen Virol 82:2973–2977
    [Google Scholar]
  17. Nerrienet E., Meertens L., Kfutwah A., Foupouapouognigni Y., Ayouba A., Gessain A. 2004; Simian T cell leukaemia virus type I subtype B in a wild-caught gorilla ( Gorilla gorilla gorilla ) and chimpanzee ( Pan troglodytes vellerosus ) from Cameroon. J Gen Virol 85:25–29 [CrossRef]
    [Google Scholar]
  18. Peeters M., Courgnaud V., Abela B. 11 other authors 2002; Risk to human health from a plethora of simian immunodeficiency viruses in primate bushmeat. Emerg Infect Dis 8:451–457 [CrossRef]
    [Google Scholar]
  19. Sandstrom P. A., Phan K. O., Switzer W. M., Fredeking T., Chapman L., Heneine W., Folks T. M. 2000; Simian foamy virus infection among zoo keepers. Lancet 355:551–552 [CrossRef]
    [Google Scholar]
  20. Santiago M. L., Rodenburg C. M., Kamenya S. 21 other authors 2002; SIVcpz in wild chimpanzees. Science 295:465 [CrossRef]
    [Google Scholar]
  21. Schweizer M., Neumann-Haefelin D. 1995; Phylogenetic analysis of primate foamy viruses by comparison of pol sequences. Virology 207:577–582 [CrossRef]
    [Google Scholar]
  22. Schweizer M., Falcone V., Gange J., Turek R., Neumann-Haefelin D. 1997; Simian foamy virus isolated from an accidentally infected human individual. J Virol 71:4821–4824
    [Google Scholar]
  23. Slattery J. P., Franchini G., Gessain A. 1999; Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses. Genome Res 9:525–540
    [Google Scholar]
  24. Switzer W. M., Bhullar V., Shanmugam V. 9 other authors 2004; Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates. J Virol 78:2780–2789 [CrossRef]
    [Google Scholar]
  25. Tobaly-Tapiero J., Bittoun P., Neves M. 8 other authors 2000; Isolation and characterization of an equine foamy virus. J Virol 74:4064–4073 [CrossRef]
    [Google Scholar]
  26. Verschoor E. J., Langenhuijzen S., van den Engel S., Niphuis H., Warren K. S., Heeney J. L. 2003; Structural and evolutionary analysis of an orangutan foamy virus. J Virol 77:8584–8587 [CrossRef]
    [Google Scholar]
  27. Voevodin A., Samilchuk E., Schatzl H., Boeri E., Franchini G. 1996; Interspecies transmission of macaque simian T-cell leukemia/lymphoma virus type 1 in baboons resulted in an outbreak of malignant lymphoma. J Virol 70:1633–1639
    [Google Scholar]
  28. Wolfe N. D., Switzer W. M., Carr J. K. 12 other authors 2004; Naturally acquired simian retrovirus infections in central African hunters. Lancet 363:932–937 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.80241-0
Loading
/content/journal/jgv/10.1099/vir.0.80241-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error