@article{mbs:/content/journal/jgv/10.1099/vir.0.80437-0, author = "Moum, Truls and Olsaker, Ingrid and Hopp, Petter and Moldal, Torfinn and Valheim, Mette and Moum, Torbjørn and Benestad, Sylvie L.", title = "Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases", journal= "Journal of General Virology", year = "2005", volume = "86", number = "1", pages = "231-235", doi = "https://doi.org/10.1099/vir.0.80437-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80437-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Until June 2004, thirty-eight scrapie cases with unusual features, designated Nor98, have been diagnosed in Norway. This study investigated the distribution of PrP genotypes among Nor98 cases, their flock-mates and a random sample of Norwegian slaughtered sheep. The PrP genotype distribution of Nor98 cases differed markedly from that of previous cases of classical scrapie. A leucine/phenylalanine polymorphism at codon 141 with hitherto unknown significance to scrapie was strongly associated with Nor98 cases. Twenty of 38 (52·6 %) cases were either homozygous or heterozygous for phenylalanine at codon 141. In contrast, this allele was present in only 10·5 % of the flock-mates and 4·5 % of the random sample of slaughtered sheep. Moreover, the H154 allele was represented in 24 of 38 (63·2 %) of Nor98 cases, as opposed to 27·0 % of Nor98 flock-mates and 17·0 % of the slaughtered sheep.", }