1887

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Volume 86, Issue 3

Regulation of human immunodeficiency virus 1 transcription by microRNA Free

Abstract

MicroRNAs (miRNAs) are ∼21–25 nt long and interact with mRNAs to lead to either translational repression or RNA cleavage through RNA interference. A previous study showed that human immunodeficiency virus 1 (HIV-1) dsRNA from AIDS patients who are long-term non-progressors inhibited HIV-1 transcription. In the study reported here, -derived miRNAs in HIV-1-infected and transduced cells were identified, and showed that HIV-1 transcription was suppressed by -expressing miRNA, miR-N367, in human T cells. The miR-N367 could reduce HIV-1 LTR promoter activity through the negative responsive element of the U3 region in the 5′-LTR. Therefore, miRNA produced in HIV-1-infected cells may downregulate HIV-1 transcription through both a post-transcriptional pathway and a transcriptional neo-pathway.

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2005-03-01
2024-04-19
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Regulation of human immunodeficiency virus 1 transcription by nef microRNA
J. Gen. Virol. 86, 751 (2005); https://doi.org/10.1099/vir.0.80449-0
/content/journal/jgv/10.1099/vir.0.80449-0
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