Murine gammaherpesvirus-68 ORF28 encodes a non-essential virion glycoprotein
May, Janet S. and Coleman, Heather M. and Boname, Jessica M. and Stevenson, Philip G.,, 86, 919-928 (2005),
doi = https://doi.org/10.1099/vir.0.80661-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Murine gammaherpesvirus-68 (MHV-68) ORF28 is a gammaherpesvirus-specific gene of unknown function. Analysis of epitope-tagged ORF28 protein indicated that it was membrane-associated and incorporated into virions in N-glycosylated, O-glycosylated and unglycosylated forms. The extensive glycosylation of the small ORF28 extracellular domain – most forms of the protein appeared to be mainly carbohydrate by weight – suggested that a major function of ORF28 is to attach a variety of glycans to the virion surface. MHV-68 lacking ORF28 showed normal lytic replication in vitro and in vivo and normal latency establishment. MHV-68 ORF28 therefore encodes a small, membrane-bound and extensively glycosylated virion protein, whose function is entirely dispensable for normal, single-cycle host colonization.,
language=,
type=