1887

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Volume 86, Issue 4

Murine gammaherpesvirus-68 ORF28 encodes a non-essential virion glycoprotein Free

Abstract

Murine gammaherpesvirus-68 (MHV-68) ORF28 is a gammaherpesvirus-specific gene of unknown function. Analysis of epitope-tagged ORF28 protein indicated that it was membrane-associated and incorporated into virions in -glycosylated, -glycosylated and unglycosylated forms. The extensive glycosylation of the small ORF28 extracellular domain – most forms of the protein appeared to be mainly carbohydrate by weight – suggested that a major function of ORF28 is to attach a variety of glycans to the virion surface. MHV-68 lacking ORF28 showed normal lytic replication and and normal latency establishment. MHV-68 ORF28 therefore encodes a small, membrane-bound and extensively glycosylated virion protein, whose function is entirely dispensable for normal, single-cycle host colonization.

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2005-04-01
2024-04-16
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Murine gammaherpesvirus-68 ORF28 encodes a non-essential virion glycoprotein
J. Gen. Virol. 86, 919 (2005); https://doi.org/10.1099/vir.0.80661-0
/content/journal/jgv/10.1099/vir.0.80661-0
/content/journal/jgv/10.1099/vir.0.80661-0
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