1887

Abstract

The nucleotide sequence of a novel icosahedral DNA virus infecting has been determined. The genome is 5039 nt long and includes inverted terminal repeats of 200 nt containing 131 nt long J-shaped terminal hairpins. The ‘plus' strand of the genome contains three large open reading frames (ORFs), the left and the mid-ORFs (within the left ORF) in the left-half encoding the non-structural proteins and the right ORF in the right-half encoding viral capsid proteins. NS1 protein contains conserved replication initiation and DNA-dependent ATPase/helicase domains. VP1 protein contains a conserved PGY and phospholipase A2 motifs and shows high identities with VPs of densovirus and densovirus-1 belonging to the genus . Phylogenetic analysis also revealed that this virus is most closely related to densovirus and densovirus-1. Consequently, this virus was considered as a new third member of the genus of the subfamily , and designated densovirus.

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2005-08-01
2024-03-29
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