RT Journal Article SR Electronic(1) A1 Chamberlain, John A1 Cook, Nicola A1 Lloyd, Graham A1 Mioulet, Valerie A1 Tolley, Howard A1 Hewson, RogerYR 2005 T1 Co-evolutionary patterns of variation in small and large RNA segments of Crimean-Congo hemorrhagic fever virus JF Journal of General Virology, VO 86 IS 12 SP 3337 OP 3341 DO https://doi.org/10.1099/vir.0.81213-0 PB Microbiology Society, SN 1465-2099, AB The genus Nairovirus of the family Bunyaviridae includes the Crimean-Congo haemorrhagic fever (CCHF) species group. The species is predominated by the hazard-group 4 pathogens, from which the name and majority of strain entries are derived. Additionally, the species embraces hazard-group 2 viruses that are classified as members by antigenic cross-reactivity. CCHF viruses have a tripartite RNA genome consisting of large (L), medium (M) and small (S) segments. Here, the sequence characterization of previously undescribed L and S segments from novel strains originating in the Middle East and Africa is reported. Further scrutiny of this data with phylogenetic tools, in the context of other publicly available sequence information, reveals analogous grouping patterns between the L and S segments. These groups correlate with the geographical distribution of strain isolation and indicate that the L and S segments of CCHF viruses have evolved together., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.81213-0