@article{mbs:/content/journal/jgv/10.1099/vir.0.81318-0, author = "Andréoletti, Olivier and Morel, Nathalie and Lacroux, Caroline and Rouillon, Virginie and Barc, Céline and Tabouret, Guillaume and Sarradin, Pierre and Berthon, Patricia and Bernardet, Philippe and Mathey, Jacinthe and Lugan, Séverine and Costes, Pierrette and Corbière, Fabien and Espinosa, Juan-Carlos and Torres, Juan Maria and Grassi, Jacques and Schelcher, François and Lantier, Frédéric", title = "Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep", journal= "Journal of General Virology", year = "2006", volume = "87", number = "4", pages = "1043-1046", doi = "https://doi.org/10.1099/vir.0.81318-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.81318-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrPSc in the spleen.", }