RT Journal Article SR Electronic(1) A1 Andréoletti, Olivier A1 Morel, Nathalie A1 Lacroux, Caroline A1 Rouillon, Virginie A1 Barc, Céline A1 Tabouret, Guillaume A1 Sarradin, Pierre A1 Berthon, Patricia A1 Bernardet, Philippe A1 Mathey, Jacinthe A1 Lugan, Séverine A1 Costes, Pierrette A1 Corbière, Fabien A1 Espinosa, Juan-Carlos A1 Torres, Juan Maria A1 Grassi, Jacques A1 Schelcher, François A1 Lantier, FrédéricYR 2006 T1 Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep JF Journal of General Virology, VO 87 IS 4 SP 1043 OP 1046 DO https://doi.org/10.1099/vir.0.81318-0 PB Microbiology Society, SN 1465-2099, AB Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrPSc in the spleen., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.81318-0