Human herpesvirus 6 envelope cholesterol is required for virus entry
Huang, Honglan and Li, Yongmei and Sadaoka, Tomohiko and Tang, Huanmin and Yamamoto, Takahito and Yamanishi, Koichi and Mori, Yasuko,, 87, 277-285 (2006),
doi = https://doi.org/10.1099/vir.0.81551-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= In this study, the role of cholesterol in the envelope of human herpesvirus 6 (HHV-6) was examined by using methyl-β-cyclodextrin (MβCD) depletion. When cholesterol was removed from HHV-6 virions with MβCD, infectivity was abolished, but it could be rescued by the addition of exogenous cholesterol. HHV-6 binding was affected slightly by MβCD treatment. In contrast, envelope cholesterol depletion markedly affected HHV-6 infectivity and HHV-6-induced cell fusion. These results suggest that the cholesterol present in the HHV-6 envelope plays a prominent role in the fusion process and is a key component in viral entry.,
language=,
type=