@article{mbs:/content/journal/jgv/10.1099/vir.0.81606-0, author = "Luebcke, Emily and Dubovi, Edward and Black, Darla and Ohsawa, Kazutaka and Eberle, Richard", title = "Isolation and characterization of a chimpanzee alphaherpesvirus", journal= "Journal of General Virology", year = "2006", volume = "87", number = "1", pages = "11-19", doi = "https://doi.org/10.1099/vir.0.81606-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.81606-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Although both beta- and gammaherpesviruses indigenous to great-ape species have been isolated, to date all alphaherpesviruses isolated from apes have proven to be human viruses [herpes simplex virus types 1 (HSV1) and 2 (HSV2) or varicella-zoster virus]. If the alphaherpesviruses have co-evolved with their host species, some if not all ape species should harbour their own alphaherpesviruses. Here, the isolation and characterization of an alphaherpesvirus from a chimpanzee (ChHV) are described. Sequencing of a number of genes throughout the ChHV genome indicates that it is collinear with that of HSV. Phylogenetic analyses place ChHV in a clade with HSV1 and HSV2, the alphaherpesviruses of Old World monkeys comprising a separate clade. Analysis of reactivity patterns of HSV2-immune human sera and ChHV-immune chimpanzee sera by competition ELISA support this relationship. Phylogenetic analyses also place ChHV rather than HSV1 as the closest relative of HSV2.", }