RT Journal Article SR Electronic(1) A1 Abdel-Hamid, Mohamed A1 El-Daly, Mai A1 Molnegren, Vilma A1 El-Kafrawy, Sherif A1 Abdel-Latif, Sohair A1 Esmat, Gamal A1 Strickland, G. Thomas A1 Loffredo, Christopher A1 Albert, Jan A1 Widell, AndersYR 2007 T1 Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma JF Journal of General Virology, VO 88 IS 5 SP 1526 OP 1531 DO https://doi.org/10.1099/vir.0.82626-0 PB Microbiology Society, SN 1465-2099, AB Egypt has one of the world’s highest prevalences of hepatitis C virus (HCV) infection, with a majority of genotype 4 infections. To explore the genetic diversity of HCV in Egypt, sera from 131 Egyptians [56 from community studies, 37 chronic hepatitis patients, 28 hepatocellular carcinoma (HCC) patients and 10 patients with non-Hodgkin’s lymphoma] were genotyped by restriction fragment-length polymorphism and phylogenetic analyses of sequences from the mid-core and non-structural 5B regions. The different genotyping methods showed good agreement. The majority of the viruses (83 of 131; 63 %) were of subtype 4a, but five other subtypes within genotype 4 were also observed, as well as three genotype 1b, five genotype 1g and one genotype 3a samples. Interestingly, subtype 4o, which was easily identifiable in all three genomic regions, showed an association with HCC (P=0.017), which merits further investigation., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.82626-0