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Abstract

Genetic analysis of all eight genes of two Nanchang avian influenza viruses, A/Duck/Nanchang/1681/92 (H3N8-1681) and A/Duck/Nanchang/1904/92 (H7N1-1904), isolated from Jiangxi province, China, in 1992, showed that six internal genes of H3N8-1681 virus and five internal (except NS gene) genes of H7N1-1904 virus were closely similar to A/Goose/Guangdong/1/96 (H5N1) virus, the first highly pathogenic avian influenza (HPAI) virus of subtype H5N1 isolated in Asia. The neuraminidase (NA) gene of Gs/Gd/1/96 had the highest genetic similarity with A/Duck/Hokkaido/55/96 (H1N1-55) virus. The haemagglutinin (HA) gene of Gs/Gd/1/96 virus might have originated as a result of mutation of H5 HA gene from A/Swan/Hokkaido/51/96 (H5N3-51)-like viruses. The PA gene of H5N3-51 virus had the highest similarity with Gs/Gd/1/96. This study explains the origin of first Asian HPAI H5N1 virus in Guangdong by the reassortment of Nanchang (close to Guangdong) and Hokkaido (Japan) (H1N1-55 and H5N3-51) viruses. Genetic characteristics of donor and recipient viruses were also studied.

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2007-11-01
2024-03-28
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References

  1. Alexander D. J. 2000; A review of avian influenza in different bird species. Vet Microbiol 74:3–13 [CrossRef]
    [Google Scholar]
  2. Bender C., Hall H., Huang J., Klimov A., Cox N. J., Gregory V., Cameron K., Lim W., Subbarao K. 1999; Characterization of the surface protein of influenza A (H5N1) viruses isolated from humans in 1997–1998. Virology 254:115–123 [CrossRef]
    [Google Scholar]
  3. Chang S., Zhang J., Liao X., Zhu X., Wang D., Zhu J., Feng T., Zhu B., Gao G. F. other authors 2007; Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research. Nucleic Acids Res 35: (Database issue), D376–D380 [CrossRef]
    [Google Scholar]
  4. Gabriel G., Dauber B., Wolff T., Planz O., Klenk H. D., Stech J. 2005; The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci U S A 102:18590–18595 [CrossRef]
    [Google Scholar]
  5. Gao P., Watanabe S., Ito T., Goto H., Wells K., McGregor M., Cooley A. J., Kawaoka Y. 1999; Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong. J Virol 73:3184–3189
    [Google Scholar]
  6. Guan Y., Shortridge K. F., Krauss S., Webster R. G. 1999; Molecular characterization of H9N2 influenza viruses: were they the donors of the “internal” genes of H5N1 viruses in Hong Kong?. Proc Natl Acad Sci U S A 96:9363–9367 [CrossRef]
    [Google Scholar]
  7. Guindon S., Gascuel O. 2003; A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52:696–704 [CrossRef]
    [Google Scholar]
  8. Hatta M., Gao P., Halfmann P., Kawaoka Y. 2001; Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 293:1840–1842 [CrossRef]
    [Google Scholar]
  9. Hiromoto Y., Yamazaki Y., Fukushima T., Saito T., Lindstrom S., Omoe K., Nerome R., Lim W., Sugita S., Nerome K. 2000; Evolutionary characterization of the six internal genes of H5N1 human influenza A virus. J Gen Virol 81:1293–1303
    [Google Scholar]
  10. Hoffmann E., Stech J., Leneva I., Krauss S., Scholtissek C., Chin P. S., Peiris M., Shortridge K. F., Webster R. G. 2000; Characterization of the influenza A virus gene pool in avian species in southern China: was H6N1 a derivative or a precursor of H5N1?. J Virol 74:6309–6315 [CrossRef]
    [Google Scholar]
  11. Katz J. M., Lu X., Tumpey T. M., Smith C. B., Shaw M. W., Subbarao K. 2000; Molecular correlates of influenza A H5N1 virus pathogenesis in mice. J Virol 74:10807–10810 [CrossRef]
    [Google Scholar]
  12. Kawaoka Y., Naeve C. W., Webster R. G. 1984; Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin?. Virology 139:303–316 [CrossRef]
    [Google Scholar]
  13. Krug R. M. 2006; Clues to the virulence of H5N1 viruses in humans. Science 311:1562–1563 [CrossRef]
    [Google Scholar]
  14. Kumar S., Tamura K., Nei M. 2004; mega3: integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 5:150–163 [CrossRef]
    [Google Scholar]
  15. Ludwig S., Schultz U., Mandler J., Fitch W. M., Scholtissek C. 1991; Phylogenetic relationship of the nonstructural (NS) genes of influenza A viruses. Virology 183:566–577 [CrossRef]
    [Google Scholar]
  16. Macken C., Lu H., Goodman J., Boykin L. 2001; The value of a database in surveillance and vaccine selection. In Options for the Control of Influenza IV : proceedings of the World Congress on Options for the Control of Influenza IV. Crete: 23–28 September 2000 pp 103–106 Edited by Osterhaus A. D. M. E., Cox N., Hampson A. W. Amsterdam: Elsevier Science;
  17. NCBI 2007; Influenza Virus Resource. Available from http://www.ncbi.nlm.nih.gov/genomes/FLU/
  18. Obenauer J. C., Denson J., Mehta P. K., Su X., Mukatira S., Finkelstein D. B., Xu X., Wang J., Ma J. other authors 2006; Large-scale sequence analysis of avian influenza isolates. Science 311:1576–1580 [CrossRef]
    [Google Scholar]
  19. Scholtissek C., Burger H., Kistner O., Shortridge K. F. 1985; The nucleoprotein as a possible major factor in determining host specificity of influenza H3N2 viruses. Virology 147:287–294 [CrossRef]
    [Google Scholar]
  20. Senne D. A., Panigrahy B., Kawaoka Y., Pearson J. E., Suss J., Lipkind M., Kida H., Webster R. G. 1996; Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential. Avian Dis 40:425–437 [CrossRef]
    [Google Scholar]
  21. Seo S. H., Hoffmann E., Webster R. G. 2002; Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nat Med 8:950–954 [CrossRef]
    [Google Scholar]
  22. Sims L. D., Domenech J., Benigno C., Kahn S., Kamata A., Lubroth J., Martin V., Roeder P. 2005; Origin and evolution of highly pathogenic H5N1 avian influenza in Asia. Vet Rec 157:159–164 [CrossRef]
    [Google Scholar]
  23. Subbarao K., Shaw M. W. 2000; Molecular aspects of avian influenza (H5N1) viruses isolated from humans. Rev Med Virol 10:337–348 [CrossRef]
    [Google Scholar]
  24. Subbarao E. K., London W., Murphy B. R. 1993; A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol 67:1761–1764
    [Google Scholar]
  25. Subbarao K., Klimov A., Katz J., Regnery H., Lim W., Hall H., Perdue M., Swayne D., Bender C. other authors 1998; Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279:393–396 [CrossRef]
    [Google Scholar]
  26. Wood G. W., Banks J., McCauley J. W., Alexander D. J. 1994; Deduced amino acid sequences of the hemagglutinin of H5N1 avian influenza virus isolates from an outbreak in turkeys in Norfolk, England. Arch Virol 134:185–194 [CrossRef]
    [Google Scholar]
  27. Xu X., Subbarao K., Cox N. J., Guo Y. 1999; Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology 261:15–19 [CrossRef]
    [Google Scholar]
  28. Zhou N. N., Shortridge K. F., Claas E. C. J., Krauss S. L., Webster R. G. 1999; Rapid evolution of H5N1 influenza viruses in chickens in Hong Kong. J Virol 73:3366–3374
    [Google Scholar]
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