Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea
Song, Ki-Joon and Baek, Luck Ju and Moon, Sungsil and Ha, Si Jung and Kim, Sang Hyun and Park, Kwang Sook and Klein, Terry A. and Sames, William and Kim, Heung-Chul and Lee, John S. and Yanagihara, Richard and Song, Jin-Won,, 88, 3121-3129 (2007),
doi = https://doi.org/10.1099/vir.0.83139-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Acute-phase sera from >5 % of cases of haemorrhagic fever with renal syndrome occurring annually in Korea have been found to exhibit a fourfold or higher antibody titre to Puumala virus (PUUV) than to Hantaan virus (HTNV) by double-sandwich IgM ELISA, suggesting the existence of a PUUV-related hantavirus. Based on the phylogenetic relationships among arvicolid rodents, the royal vole (Myodes regulus) was targeted as a likely reservoir host of hantavirus. Using RT-PCR, a genetically distinct hantavirus, designated Muju virus (MUJV), was detected in lung tissue of royal voles, captured in widely separated geographical regions in Korea during 1996–2007. Pairwise analysis of the full-length S (1857 nt) and M (3634 nt) segments of MUJV indicated approximately 77 % sequence similarity with PUUV. At the amino acid level, MUJV differed from PUUV by 5.5–6.9 % (nucleocapsid) and 10.0–11.6 % (Gn and Gc envelope glycoproteins). Interstrain variation of MUJV sequences from royal voles captured in different regions suggested geographic-specific clustering. Neutralizing antibody titres against PUUV were two- to sixfold higher than to HTNV in sera of MUJV-infected Myodes regulus. Although virus isolation attempts were unsuccessful, the collective data indicate that MUJV is a distinct hantavirus species.,
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