Full-length genome sequences of hepatitis C virus subtype 4f
Hmaied, Fatma and Legrand-Abravanel, Florence and Nicot, Florence and Garrigues, Natalie and Chapuy-Regaud, Sabine and Dubois, Martine and Njouom, Richard and Izopet, Jacques and Pasquier, Christophe,, 88, 2985-2990 (2007),
doi = https://doi.org/10.1099/vir.0.83151-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Hepatitis C virus genotype 4 (HCV-4) is very common in central Africa, prevalent in the Middle East, and is becoming increasingly frequent among southern Europeans. We have determined the complete nucleotide sequences of HCV-4f strains and investigated their phylogenetic relationships with other genotypes. We amplified the complete genome of two HCV subtype 4f strains, IFBT84 and IFBT88. The HCV-4f strains have a total of 9181 and 9304 nt, respectively, including the 5′ untranslated region followed by a single open reading frame. There was no evidence of genomic recombination in the IFBT84 and IFBT88 strains. The sequences of the HCV-4f strain genomes are closer to those of HCV-1b than to genotypes 2, 3, 5 and 6. It is important to know the full-length sequences of HCV-4 subtypes in order to classify them correctly and to obtain more detailed knowledge about HCV epidemiology and sensitivity to interferon.,
language=,
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