1887

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Volume 89, Issue 5

Restriction of human herpesvirus 6B replication by p53 Free

Abstract

Human herpesvirus 6B (HHV-6B) induces significant accumulation of p53 in both the nucleus and cytoplasm during infection. Activation of p53 by DNA damage is known to induce either growth arrest or apoptosis; nevertheless, HHV-6B-infected cells are arrested in their cell cycle independently of p53, and only a minor fraction of the infected cells undergoes apoptosis. Using pifithrin-, a p53 inhibitor, and p53-null cells, this study showed that infected epithelial cells accumulated viral transcripts and proteins to a significantly higher degree in the absence of active p53. Moreover, HHV-6B-induced cytopathic effects were greatly enhanced in the absence of p53. This suggests that, in epithelial cells, some of the functions of p53 leading to cell-cycle arrest and apoptosis are restrained by HHV-6B infection, whereas other cellular defences, causing inhibition of virus transcription, are partially retained.

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2008-05-01
2024-04-19
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Restriction of human herpesvirus 6B replication by p53
J. Gen. Virol. 89, 1106 (2008); https://doi.org/10.1099/vir.0.83262-0
/content/journal/jgv/10.1099/vir.0.83262-0
/content/journal/jgv/10.1099/vir.0.83262-0
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