1887

Abstract

Kerala State in India was gripped by a renewed and widespread outbreak of Chikungunya virus (CHIKV) infection during 2007. Here, we report the A226V mutation in the glycoprotein envelope 1 (E1) gene of the virus among isolates collected from the three worst-affected districts of the state during this outbreak. This mutation had already been suggested to be directly responsible for a significant increase in CHIKV infectivity in . The badly affected districts in Kerala State during 2007 have abundant rubber plantations, which supported prolific breeding of mosquitoes. The abundance of in the region and molecular evolution of CHIKV may be contributing factors for the renewed epidemic of chikungunya fever during 2007.

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2008-08-01
2024-04-18
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References

  1. Arankalle V. A., Shrivastava S., Cherian S., Gunjikar R. S., Walimbe A. M., Jadhav S. M., Sudeep A. B., Mishra A. C. 2007; Genetic divergence of Chikungunya viruses in India (1963–2006) with special reference to the 2005–2006 explosive epidemic. J Gen Virol 88:1967–1976 [CrossRef]
    [Google Scholar]
  2. Arogyakeralam 2008 Prevention & control of emerging fevers in Kerala State Disease Control & Monitoring Cell; http://www.arogyakeralam.gov.in/images/nwcg07/peid%20edited%20on%2004-02-08.ppt.pdf
    [Google Scholar]
  3. Hasebe F., Parquet M. C., Pandey B. D., Mathenge E. G. M., Balasubramaniam V., Saat Z., Yusop A., Sinniah M. other authors 2002; Combined detection and genotyping of Chikungunya virus by a specific reverse transcription-polymerase chain reaction. J Med Virol 67:370–374 [CrossRef]
    [Google Scholar]
  4. ICTV 2006; 00.073. Togaviridae. In ICTVdB. The Universal Virus Database, version 4Edited by Büchen-Osmond. New York: Columbia University; http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/00.073.htm
    [Google Scholar]
  5. Kimura M. 1980; A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 16:111–120 [CrossRef]
    [Google Scholar]
  6. Kumar N. P., Madhu Mitha M., Krishnamoorthy N., Kamaraj T., Joseph R., Jambulingam P. 2007; Genotyping of virus involved in the 2006 Chikungunya outbreak in South India (Kerala and Puducherry).. Curr Sci 93:1412–1416
    [Google Scholar]
  7. National Informatics Centre, Government of India 2008; Health Bulletin. Dengue fever http://india.gov.in/citizen/health/archive_index.php
    [Google Scholar]
  8. NVBDCP 2007 Chikungunya fever situation in the country during 2006 (prov.) New Delhi: National Vector Borne Disease Control Programme; http://www.nvbdcp.gov.in/Chikun-cases.html
    [Google Scholar]
  9. NVBDCP 2008 Dengue/DHF New Delhi: National Vector Borne Disease Control Programme; http://www.nvbdcp.gov.in/Dengueupdate.html
    [Google Scholar]
  10. Schuffenecker I., Iteman I., Michault A., Murri S., Frangeul L., Vaney M.-C., Lavenir R., Paradigon N., Reynes J.-M. other authors 2006; Genome microevolution of Chikungunya viruses causing the Indian Ocean outbreak. PLoS Med 3:e263 [CrossRef]
    [Google Scholar]
  11. Sumodan P. K. 2003; Potential of rubber plantations as breeding source for Aedes albopictus in Kerala, India. Dengue Bull 27:197–198 http://archives.hellis.org/documents/dbull/dbv27p197.pdf
    [Google Scholar]
  12. Tamura K., Dudley J., Nei M., Kumar S. 2007; mega4: molecular evolutionary genetics analysis (mega) software version 4.0. Mol Biol Evol 24:1596–1599 [CrossRef]
    [Google Scholar]
  13. Tsetsarkin K. A., Vanlandingham D. L., McGee C. E., Higgs S. 2007; A single mutation in chikungunya virus affects vector specificity and epidemic potential. PLoS Pathog 3:e201 [CrossRef]
    [Google Scholar]
  14. Vashishtha M., Phalen T., Marquardt M. T., Ryu J. S., Ng A. C., Kielian M. 1998; A single point mutation controls the cholesterol dependence of Semliki Forest virus entry and exit. J Cell Biol 140:91–99 [CrossRef]
    [Google Scholar]
  15. Vazeille M., Moutailler S., Coudrier D., Rousseaux C., Khun H., Kuerre M., Thiria J., Dehecq J., Fontenille D. other authors 2007; Two chikungunya isolates from the outbreak of La Réunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus . PLoS One 2:e1168 [CrossRef]
    [Google Scholar]
  16. WHO 2006 Chikungunya in India . Epidemic and Pandemic Alert and Response, 17 October 2006 Geneva: World Health Organization; http://www.who.int/csr/don/2006_10_17/en/index.html
    [Google Scholar]
  17. WHO/SEARO 2008 Chikungunya fever, a re-emerging disease in Asia New Delhi: WHO South-East Asia Regional Office; http://www.searo.who.int/en/Section10/Section2246.htm
    [Google Scholar]
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