1887

Abstract

SUMMARY

Three-week-old mice were inoculated with pseudorabies virus by means of the left hind foot pad. Infectious virus was isolated from tissues in the sequence: foot pad, sciatic nerve and dorsal root ganglion, lower, middle, upper spinal cord, and brain. Virus was recovered in one instance only from the liver, but could not be recovered from the spleen or heart blood. The involvement of the kidneys, adrenal glands, coeliac ganglion and skin in the spread of infection was also studied. The possible role of the autonomic nervous system in the pathogenesis is suggested. In this respect, immunosympathectomy prior to inoculation reduced the incidence of infection in the adrenal glands and kidneys. Interruption of the sciatic and femoral nerves led to reduced mortality and an altered pathogenesis. A new pattern of virus isolation from the tissues was observed in mice dying at later times following section or ligation of these nerves. The electron microscope observations indicated that neurons rather than glia are of major importance in facilitating virus spread within and from the nervous system.

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1974-05-01
2024-04-25
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References

  1. Becker C. H. 1968; Die Multiplikation des Aujeszkyshen Virus in den Spinalganglien des Kanichens. Archiv für experimentelle Veterinärmedizin 22:363–381
    [Google Scholar]
  2. Cook M. L., Stevens J. G. 1973; Pathogenesis of herpetic neuritis and ganglionitis in mice: Evidence for Intra-axonal transport of infection. Infection and Immunity 7:272–288
    [Google Scholar]
  3. Dean D. J., Evans W. M. 1963; Pathogenesis of tetanus and pseudorabies. Annual Report, Division of Laboratory Research, New York State Health Department p 49
    [Google Scholar]
  4. Dillard S. H., Cheatham W. J., Moses H. L. 1972; Electron microscopy of zosteriform herpes simplex infection in the mouse. Laboratory Investigation 26:391–402
    [Google Scholar]
  5. Fraser G., Ramachandran S. P. 1969; Studies on the virus of Aujesky’s disease I. Pathogenicity for rats and mice. Journal of Comparative Pathology 79:435–444
    [Google Scholar]
  6. GoodPasture E. W., Teague O. 1923; Transmission of the virus of herpes febrilis along nerves in experimentally infected rabbits. Journal of Medical Research 44:139–184
    [Google Scholar]
  7. Hill T. J., Field H. J. 1973; The interaction of herpes simplex virus with cultures of peripheral nervous tissue: an electron microscopic study. Journal of General Virology 21:123–133
    [Google Scholar]
  8. Hill T. J., Field H. J., Roome A. P. C. 1972; Intra-axonal location of herpes simplex virus particles. Journal of General Virology 15:253–255
    [Google Scholar]
  9. Hurst E. W. 1933; Studies on pseudorabies (infectious bulbar paralysis, mad itch). I. Histology of the disease with a note on the symptomatology. Journal of Experimental Medicine 58:415–433
    [Google Scholar]
  10. Johnson R. T. 1964; The pathogenesis of herpes virus encephalitis. I. Virus pathways to the central nervous system of suckling mice demonstrated by fluorescent antibody staining. Journal of Experimental Medicine 119:343–356
    [Google Scholar]
  11. Klingman G. I., Klingman J. D. 1972; Effects of immunosympathectomy on biogenic amines and cholinesterases. In Nerve Growth Factor and its Antiserum pp 125–145 Edited by Zaimis E., Knight J. University of London: The Athlone Press;
    [Google Scholar]
  12. Kristensson K., Lycke E., Sjöstrand J. 1971a; Spread of herpes simplex virus in peripheral nerves. Acta neuropathologica, Berlin 17:44–53
    [Google Scholar]
  13. Kristensson K., Olsson Y., Sjöstrand J. 1971b; Axonal uptake and retrograde transport of exogenous proteins in the hypoglossal nerve. Brain research 32:399–406
    [Google Scholar]
  14. Kristensson K., Olsson Y. 1973; Diffusion pathways and retrograde axonal transport of protein tracers in peripheral nerves. Progress in Neurobiology I:87–104
    [Google Scholar]
  15. Levi-montalcini R., Booker B. 1960; Destruction of the sympathetic ganglia in mammals by an antiserum to nerve growth factor. Proceedings of the National Academy of Sciences of the United States of America 46:384–391
    [Google Scholar]
  16. McFerran J. B., Dow C. 1965; The distribution of the virus of Aujeszky’s disease (pseudorabies virus) in experimentally infected swine. American Journal of Veterinary Research 26:631–635
    [Google Scholar]
  17. McCracken R. M., McFerran J. B., Dow C. 1973; The neural spread of pseudorabies virus in calves. Journal of General Virology 20:17–28
    [Google Scholar]
  18. Murphy F. A., Harrison A. K., Winn W. C., Bauer J. P. 1973; Comparative pathogenesis of rabies and rabies-like viruses: infection of the central nervous system and centrifugal spread of virus to peripheral tissues. Laboratory Investigation 29:1–16
    [Google Scholar]
  19. Wildy P. 1967; The progression of herpes simplex virus to the central nervous system of the mouse. Journal of Hygiene London 65:173–192
    [Google Scholar]
  20. Wright G. P. 1953; Nerve trunks as pathways in infection. Proceedings of the Royal Society of Medicine 46:319–330
    [Google Scholar]
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