1887

Abstract

Human enterovirus 68 (EV-D68) is a historically rarely reported virus linked with respiratory disease. In the past 3 years, a large increase in respiratory disease associated with EV-D68 has been reported, with documented outbreaks in North America, Europe and Asia. In several outbreaks, genetic differences were identified among the circulating strains, indicating the presence of multiple clades. In this report, we analyse archived and novel EV-D68 strains from Africa and the USA, obtained from patients with respiratory illness. Phylogenetic analysis of all EV-D68 sequences indicates that, over the past two decades, multiple clades of the virus have emerged and spread rapidly worldwide. All clades appear to be currently circulating and contributing to respiratory disease.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.043935-0
2012-09-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/93/9/1952.html?itemId=/content/journal/jgv/10.1099/vir.0.043935-0&mimeType=html&fmt=ahah

References

  1. Briese T., Palacios G., Kokoris M., Jabado O., Liu Z., Renwick N., Kapoor V., Casas I., Pozo F. other authors 2005; Diagnostic system for rapid and sensitive differential detection of pathogens. Emerg Infect Dis 11:310–313 [View Article][PubMed]
    [Google Scholar]
  2. CDC 2011; Clusters of acute respiratory illness associated with human enterovirus 68 – Asia, Europe, and United States, 2008–2010. MMWR Morb Mortal Wkly Rep 60:1301–1304[PubMed]
    [Google Scholar]
  3. Coiras M. T., Aguilar J. C., García M. L., Casas I., Pérez-Breña P. 2004; Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays. J Med Virol 72:484–495 [View Article][PubMed]
    [Google Scholar]
  4. Drummond A. J., Rambaut A. 2007; beast: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol 7:214 [View Article][PubMed]
    [Google Scholar]
  5. Gromeier M., Alexander L., Wimmer E. 1996; Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants. Proc Natl Acad Sci U S A 93:2370–2375 [View Article][PubMed]
    [Google Scholar]
  6. Guindon S., Gascuel O. 2003; A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52:696–704 [CrossRef]
    [Google Scholar]
  7. Hasegawa S., Hirano R., Okamoto-Nakagawa R., Ichiyama T., Shirabe K. 2011; Enterovirus 68 infection in children with asthma attacks: virus-induced asthma in Japanese children. Allergy 66:1618–1620 [View Article][PubMed]
    [Google Scholar]
  8. Ikeda T., Mizuta K., Abiko C., Aoki Y., Itagaki T., Katsushima F., Katsushima Y., Matsuzaki Y., Fuji N. other authors 2012; Acute respiratory infections due to enterovirus 68 in Yamagata, Japan between 2005 and 2010. Microbiol Immunol 56:139–143 [View Article][PubMed]
    [Google Scholar]
  9. Imamura T., Fuji N., Suzuki A., Tamaki R., Saito M., Aniceto R., Galang H., Sombrero L., Lupisan S., Oshitani H. 2011; Enterovirus 68 among children with severe acute respiratory infection, the Philippines. Emerg Infect Dis 17:1430–1435[PubMed]
    [Google Scholar]
  10. Jacobson L. M., Redd J. T., Schneider E., Lu X., Chern S. W., Oberste M. S., Erdman D. D., Fischer G. E., Armstrong G. L. other authors 2012; Outbreak of lower respiratory tract illness associated with human enterovirus 68 among American Indian children. Pediatr Infect Dis J 31:309–312 [View Article][PubMed]
    [Google Scholar]
  11. Kaida A., Kubo H., Sekiguchi J., Kohdera U., Togawa M., Shiomi M., Nishigaki T., Iritani N. 2011; Enterovirus 68 in children with acute respiratory tract infections, Osaka, Japan. Emerg Infect Dis 17:1494–1497[PubMed]
    [Google Scholar]
  12. Khetsuriani N., Lamonte-Fowlkes A., Oberst S., Pallansch M. A. Centers for Disease Control and Prevention 2006; Enterovirus surveillance – United States, 1970–2005. MMWR Surveill Summ 55:1–20[PubMed]
    [Google Scholar]
  13. Lamson D., Renwick N., Kapoor V., Liu Z., Palacios G., Ju J., Dean A., St George K., Briese T., Lipkin W. I. 2006; MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004–2005. J Infect Dis 194:1398–1402 [View Article][PubMed]
    [Google Scholar]
  14. Li R., Zou Q., Chen L., Zhang H., Wang Y. 2011; Molecular analysis of virulent determinants of enterovirus 71. PLoS ONE 6:e26237 [View Article][PubMed]
    [Google Scholar]
  15. Meijer A., van der Sanden S., Snijders B. E., Jaramillo-Gutierrez G., Bont L., van der Ent C. K., Overduin P., Jenny S. L., Jusic E. other authors 2012; Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010. Virology 423:49–57 [View Article][PubMed]
    [Google Scholar]
  16. Oberste M. S., Maher K., Kilpatrick D. R., Flemister M. R., Brown B. A., Pallansch M. A. 1999a; Typing of human enteroviruses by partial sequencing of VP1. J Clin Microbiol 37:1288–1293[PubMed]
    [Google Scholar]
  17. Oberste M. S., Maher K., Kilpatrick D. R., Pallansch M. A. 1999b; Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification. J Virol 73:1941–1948[PubMed]
    [Google Scholar]
  18. Oberste M. S., Maher K., Schnurr D., Flemister M. R., Lovchik J. C., Peters H., Sessions W., Kirk C., Chatterjee N. other authors 2004; Enterovirus 68 is associated with respiratory illness and shares biological features with both the enteroviruses and the rhinoviruses. J Gen Virol 85:2577–2584 [View Article][PubMed]
    [Google Scholar]
  19. Petitjean-Lecherbonnier J., Dina J., Nguyen E., Gouarin S., Lebigot E., Vabret A. 2011; [Molecular diagnosis of respiratory enterovirus infections: use of PCR and molecular identification for a best approach of the main circulating strains during 2008]. Pathol Biol (Paris) 59:113–121 (in French) [View Article][PubMed]
    [Google Scholar]
  20. Piralla A., Baldanti F., Gerna G. 2011; Phylogenetic patterns of human respiratory picornavirus species, including the newly identified group C rhinoviruses, during a 1-year surveillance of a hospitalized patient population in Italy. J Clin Microbiol 49:373–376 [View Article][PubMed]
    [Google Scholar]
  21. Racaniello R. V. 2001; Picornaviridae: the viruses and their replication. In Fields Virology, 4th edn. vol. 1 pp. 685–722 Edited by Fields B. N., Knipe D. M., Howley. P. M. Philadelphia, PA:: Lippincott Williams & Wilkins;
    [Google Scholar]
  22. Rahamat-Langendoen J., Riezebos-Brilman A., Borger R., van der Heide R., Brandenburg A., Schölvinck E., Niesters H. G. 2011; Upsurge of human enterovirus 68 infections in patients with severe respiratory tract infections. J Clin Virol 52:103–106 [View Article][PubMed]
    [Google Scholar]
  23. Schieble J. H., Fox V. L., Lennette E. H. 1967; A probable new human picornavirus associated with respiratory diseases. Am J Epidemiol 85:297–310[PubMed]
    [Google Scholar]
  24. Tokarz R., Kapoor V., Wu W., Lurio J., Jain K., Mostashari F., Briese T., Lipkin W. I. 2011; Longitudinal molecular microbial analysis of influenza-like illness in New York City, May 2009 through May 2010. Virol J 8:288 [View Article][PubMed]
    [Google Scholar]
  25. Wang Z., Malanoski A. P., Lin B., Long N. C., Leski T. A., Blaney K. M., Hansen C. J., Brown J., Broderick M. other authors 2010; Broad spectrum respiratory pathogen analysis of throat swabs from military recruits reveals interference between rhinoviruses and adenoviruses. Microb Ecol 59:623–634 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.043935-0
Loading
/content/journal/jgv/10.1099/vir.0.043935-0
Loading

Data & Media loading...

Supplements

Supplementary material 1

PDF
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error