Immunological Relationship between Herpes Simplex and Varicella-zoster Viruses Demonstrated by Complement-fixation, Neutralization and Fluorescent Antibody Tests Schmidt, Nathalie J. and Lennette, E. H. and Magoffin, R. L.,, 4, 321-328 (1969), doi = https://doi.org/10.1099/0022-1317-4-3-321, publicationName = Microbiology Society, issn = 0022-1317, abstract= Summary The antigenic relationship between the viruses of varicella-zoster and herpes simplex was studied by complement-fixation, fluorescent antibody staining and neutralization tests. Twenty-three of 75 patients with herpes simplex infections showed significant heterologous increases in complement-fixing antibody titre to varicella-zoster virus. These heterologous increases occurred in patients with serological evidence of a prior infection with varicella-zoster virus, and the greatest proportion occurred in patients in the younger age groups who had probably experienced the most recent varicella-zoster virus infections. Five of 42 patients with varicella-zoster infections showed heterologous complement-fixing antibody responses to herpes simplex virus; all were patients with serological evidence of a prior herpes simplex virus infection. The patients with herpes simplex infection who showed heterologous complement-fixing antibody responses to varicella-zoster virus also showed marked increases in neutralizing antibody and antibody demonstrable by immunofluorescent staining. However, none of the patients with varicella-zoster infection who showed heterologous increases in complement-fixing antibody titre to herpes simplex virus had significant increases in neutralizing antibody., language=, type=