%0 Journal Article %A Stiff, Mary I. %A Olsen, Richard G. %T Effects of Retrovirus Protein on the Feline One-way Mixed Leukocyte Reaction %D 1983 %J Journal of General Virology, %V 64 %N 4 %P 957-959 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-64-4-957 %K FeLV %K immunosuppression %K MLR %K retrovirus %I Microbiology Society, %X SUMMARY The objective of this study was to evaluate the effects of feline retrovirus protein on cat lymphocyte recognition of allogeneic cells in the mixed leukocyte reaction (MLR), using u.v.-inactivated feline leukaemia virus (FeLV) and a non-disease-producing endogenous cat virus (RD-114). Twenty micrograms of u.v.-inactivated virus protein from each virus were added to mixed leukocyte cultures. FeLV induced significant suppression of the MLR (P < 0.005) whereas no significant suppression was found using RD-114. Since feline leukaemia infection is associated with immunosuppression, the retrovirus proteins may be interfering with the response of immunocompetent cells when they are confronted with an altered host cell. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-64-4-957