Immunological Variation in the ‘Common Region’ of the T Antigens of Polyoma Virus
Street, Alasdair J. and Griffin, Beverly E.,, 68, 3153-3164 (1987),
doi = https://doi.org/10.1099/0022-1317-68-12-3153,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= SUMMARY Characterization of a series of mouse monoclonal antibodies (designated αPy C21 to 26) against the region common to the large, middle and small T antigens of polyoma virus has revealed immunological diversities among the N termini of these antigens. Four of the antibodies (αPy C21 to 24) appeared to recognize all the T antigens present in lytically infected cells, but two of them (αPy C25, 26) failed to immunoprecipitate small T antigen either from 35S- or 32P-labelled cells and recognized only a subset of middle and large T antigens. None of the antibodies recognized the protein kinase activity normally associated with middle T antigen or the 60K mol. wt. antigen-related protein observed in polyoma virus lytically infected or transformed cells. The possible immunodominance of the N termini of the early gene products (as well as VP1) in the natural host of polyoma virus and the observed antigenic heterogeneity are considered.,
language=,
type=