@article{mbs:/content/journal/jgv/10.1099/0022-1317-68-5-1289, author = "Ito, Yasuhiko and Tsurdome, Masato and Hishiyama, Michiko and Yamada, Akio", title = "Immunological Interrelationships Among Human and Non-human Paramyxoviruses Revealed by Immunoprecipitation", journal= "Journal of General Virology", year = "1987", volume = "68", number = "5", pages = "1289-1297", doi = "https://doi.org/10.1099/0022-1317-68-5-1289", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-5-1289", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", keywords = "immunoprecipitation", keywords = "paramyxoviruses", keywords = "antigenic groups", abstract = "SUMMARY Antigenic interrelationships among paramyxoviruses were examined by immunoprecipitation of isotope-labelled virus-infected cell lysates with specific antisera against virions or virus components. Sendai virus, human parainfluenza virus type 1 (Pa-1) and human parainfluenza virus type 3 (Pa-3) belonged to one antigenic group, and human parainfluenza virus type 2 (Pa-2), human parainfluenza virus type 4 (Pa-4), mumps virus (MuV) and simian virus 5 to a second group. Furthermore, the human paramyxoviruses Pa-1, Pa-2, Pa-3, Pa-4 and MuV formed a single antigenic group which overlapped the above groups. Although Newcastle disease virus (NDV) belonged to a separate group it showed some cross-reaction with the human paramyxoviruses. In particular, certain batches of anti-NDV antisera reacted with the fusion (F) polypeptide of Pa-2 and the reciprocal reaction of anti-Pa-2 antiserum with NDV F was also found. The nucleoprotein showed the broadest cross-reactions among these paramyxoviruses, whereas the matrix polypeptide exhibited antigenic individuality. The nucleoprotein of MuV was most cross-reactive. Pa-2 haemagglutinin- neuraminidase (HN) and anti-MuV HN serum showed cross-reactivity with various antisera and antigens.", }