Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo
Sunil-Chandra, N. P. and Efstathiou, S. and Nash, A. A.,, 73, 3275-3279 (1992),
doi = https://doi.org/10.1099/0022-1317-73-12-3275,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Murine gammaherpesvirus 68 (MHV-68) is able to persist in spleen cells of infected mice. To determine the cell type harbouring persistent virus, spleen cells from infected animals were separated into immunoglobulin (Ig)-positive (B cell-enriched), Ig-negative (T cell-enriched) and plastic-adherent (macrophage-enriched) fractions. These cells were co-cultivated with permissive BHK-21 cells in an infectious centre assay. The consistent recovery and enrichment of infectious centres in the Ig-positive fraction clearly demonstrates that B cells are a major site of virus persistence/latency. This observation indicates that MHV-68 is biologically similar to Epstein—Barr virus and other members of the B cell lymphotropic gammaherpesvirus 1 subgroup.,
language=,
type=