Demonstration of bovine CD8+ T-cell responses to foot-and-mouth disease virus
Childerstone, Amanda J. and Cedillo-Baron, Leticia and Foster-Cuevas, Mildred and Parkhouse, R. Michael E.,, 80, 663-669 (1999),
doi = https://doi.org/10.1099/0022-1317-80-3-663,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= The aim of this study was to investigate the importance of cellular immunity in foot-and-mouth disease in cattle, in particular to determine whether a CD8+ T-cell response could be detected, as these cells may play a role in both immunity and virus persistence. As attempts to characterize classical cytotoxic T cells had yielded non-reproducible results, largely due to high backgrounds in control cultures, a proliferation assay was developed that was demonstrated to detect antigen-specific, MHC class I-restricted bovine CD8+ cells responding to foot-and-mouth disease virus (FMDV). Proliferative CD8+ T-cell responses were detected consistently from 10 to 14 days following infection with FMDV and typically lasted 3-4 weeks. The role of CD8+ T cells in control of the disease, in particular their relevance for the establishment of persistence, may now be investigated.,
language=,
type=