@article{mbs:/content/journal/jgv/10.1099/0022-1317-82-4-831, author = "Valentin, Hélène and Hamaia, Samir and König, Stéphane and Gazzolo, Louis", title = "Vascular cell adhesion molecule-1 induced by human T-cell leukaemia virus type 1 Tax protein in T-cells stimulates proliferation of human T-lymphocytes", journal= "Journal of General Virology", year = "2001", volume = "82", number = "4", pages = "831-835", doi = "https://doi.org/10.1099/0022-1317-82-4-831", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-4-831", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Human T-cell leukaemia/lymphotropic virus type 1 (HTLV-1), aetiologically linked to lymphoproliferative as well as inflammatory diseases, infects and activates CD4+ helper T-cells and thus alters immunoregulatory pathways. The viral regulatory Tax protein has been shown previously to induce the expression of vascular cell adhesion molecule-1 (VCAM-1) by T-cells. To determine the functional role of this adhesion molecule, Jurkat T-cells stably expressing either Tax or both Tax and Rex (another viral regulatory protein) were used in binding and coculture assays performed with either control Jurkat cells or primary human T-lymphocytes. Evidence was provided that VCAM-1 acting in synergy with leucocyte function-associated antigen-3 promotes T-cell–T-cell interactions and increases T-cell proliferation. Interestingly, Rex was found to modulate these events. These data establish that VCAM-1 induced by Tax on T-cells thus contributes to the immunopathological process triggered by HTLV-1 infection.", }