%0 Journal Article %A Azoulay-Cayla, Arièle %A Syan, Sylvie %A Brahic, Michel %A Bureau, Jean-François %T Roles of the H-2Db and H-Kb genes in resistance to persistent Theiler’s murine encephalomyelitis virus infection of the central nervous system %D 2001 %J Journal of General Virology, %V 82 %N 5 %P 1043-1047 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-82-5-1043 %I Microbiology Society, %X Theiler’s murine encephalomyelitis virus, a member of the Picornaviridae family, persists in the spinal cord of susceptible strains of mice. Resistant strains of mice, such as the H-2 b strain, clear the virus infection after an acute encephalomyelitis. The H-2D locus, but not the H-2K locus, has a major effect on this resistance, although both loci code for MHC class I molecules with similar general properties. For the present work, we rendered susceptible H-2 q FVB/N mice transgenic for either the H-2D b gene, the H-2K b gene or a chimeric H-2D b /K b gene in which the exons encoding the peptide-binding groove of the H-2K b gene have been replaced by those of the H-2D b gene. Mice transgenic for either the H-2D b gene or the chimeric H-2D b /K b gene were significantly more resistant to persistent virus infection than mice transgenic for the H-2K b gene, suggesting that the difference in the effects of the H-2D b gene and the H-2K b gene are due to the nature of the peptides presented by these class I molecules. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-5-1043