Roles of the H-2Db and H-Kb genes in resistance to persistent Theiler’s murine encephalomyelitis virus infection of the central nervous system
Azoulay-Cayla, Arièle and Syan, Sylvie and Brahic, Michel and Bureau, Jean-François,, 82, 1043-1047 (2001),
doi = https://doi.org/10.1099/0022-1317-82-5-1043,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Theiler’s murine encephalomyelitis virus, a member of the Picornaviridae family, persists in the spinal cord of susceptible strains of mice. Resistant strains of mice, such as the H-2 b strain, clear the virus infection after an acute encephalomyelitis. The H-2D locus, but not the H-2K locus, has a major effect on this resistance, although both loci code for MHC class I molecules with similar general properties. For the present work, we rendered susceptible H-2 q FVB/N mice transgenic for either the H-2D b gene, the H-2K b gene or a chimeric H-2D b /K b gene in which the exons encoding the peptide-binding groove of the H-2K b gene have been replaced by those of the H-2D b gene. Mice transgenic for either the H-2D b gene or the chimeric H-2D b /K b gene were significantly more resistant to persistent virus infection than mice transgenic for the H-2K b gene, suggesting that the difference in the effects of the H-2D b gene and the H-2K b gene are due to the nature of the peptides presented by these class I molecules.,
language=,
type=