@article{mbs:/content/journal/jgv/10.1099/0022-1317-82-9-2117, author = "Venter, Marietjie and Madhi, Shabir A. and Tiemessen, Caroline T. and Schoub, Barry D.", title = "Genetic diversity and molecular epidemiology of respiratory syncytial virus over four consecutive seasons in South Africa: identification of new subgroup A and B genotypes", journal= "Journal of General Virology", year = "2001", volume = "82", number = "9", pages = "2117-2124", doi = "https://doi.org/10.1099/0022-1317-82-9-2117", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-82-9-2117", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "The molecular epidemiology of respiratory syncytial virus (RSV) was studied over four consecutive seasons (1997–2000) in a single tertiary hospital in South Africa: 225 isolates were subgrouped by RT–PCR and the resulting products sequenced. Subgroup A predominated in two seasons, while A and B co-circulated approximately equally in the other seasons. The nucleotide sequences of the C-terminal of the G-protein were compared to sequences representative of previously defined RSV genotypes. South African subgroup A and subgroup B isolates clustered into four and five genotypes respectively. One new subgroup A and three new subgroup B genotypes were identified. Different genotypes co-circulated in every season. Different circulation patterns were identified for group A and B isolates. Subgroup A revealed more variability and displacement of genotypes while subgroup B remained more consistent.", }