1887

Abstract

A relatively small number of mosquito species transmit arboviruses such as dengue, yellow fever, chikungunya and West Nile viruses to hundreds of millions of people each year, yet we still lack a thorough understanding of the molecular factors that determine vector competence. Apoptosis has been shown to be an important factor in determining the outcome of virus infection for many viruses. However, until recently, it was not clear whether apoptosis plays a role in determining the outcome of arbovirus infections in mosquitoes. Recent work has begun to shed light on the roles of apoptosis in this important process.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/jgv.0.000429
2016-05-01
2024-04-23
Loading full text...

Full text loading...

/deliver/fulltext/jgv/97/5/1033.html?itemId=/content/journal/jgv/10.1099/jgv.0.000429&mimeType=html&fmt=ahah

References

  1. Bhatt S., Gething P. W., Brady O. J., Messina J. P., Farlow A. W., Moyes C. L., Drake J. M., Brownstein J. S., Hoen A. G., other authors. 2013; The global distribution and burden of dengue. Nature 496:504–507 [View Article][PubMed]
    [Google Scholar]
  2. Blair C. D., Olson K. E. 2015; The role of RNA interference (RNAi) in arbovirus-vector interactions. Viruses 7:820–843 [View Article][PubMed]
    [Google Scholar]
  3. Bowers D. F., Coleman C. G., Brown D. T. 2003; Sindbis virus-associated pathology in Aedes albopictus (Diptera: Culicidae). J Med Entomol 40:698–705 [View Article][PubMed]
    [Google Scholar]
  4. Campbell C. L., Keene K. M., Brackney D. E., Olson K. E., Blair C. D., Wilusz J., Foy B. D. 2008; Aedes aegypti uses RNA interference in defense against Sindbis virus infection. BMC Microbiol 8:47 [View Article][PubMed]
    [Google Scholar]
  5. Chancey C., Grinev A., Volkova E., Rios M. 2015; The global ecology and epidemiology of West Nile virus. BioMed Res Int 2015:376230 [View Article][PubMed]
    [Google Scholar]
  6. Clem R. J. 2007; Baculoviruses and apoptosis: a diversity of genes and responses. Curr Drug Targets 8:1069–1074 [View Article][PubMed]
    [Google Scholar]
  7. Franz A. W., Kantor A. M., Passarelli A. L., Clem R. J. 2015; Tissue barriers to arbovirus infection in mosquitoes. Viruses 7:3741–3767 [View Article][PubMed]
    [Google Scholar]
  8. Girard Y. A., Popov V., Wen J., Han V., Higgs S. 2005; Ultrastructural study of West Nile virus pathogenesis in Culex pipiens quinquefasciatus (Diptera: Culicidae). J Med Entomol 42:429–444 [View Article][PubMed]
    [Google Scholar]
  9. Girard Y. A., Schneider B. S., McGee C. E., Wen J., Han V. C., Popov V., Mason, P W., Higgs S. 2007; Salivary gland morphology and virus transmission during long-term cytopathologic West Nile virus infection in Culex mosquitoes. Am J Trop Med Hyg 76:118–128[PubMed]
    [Google Scholar]
  10. Harris K. G., Coyne C. B. 2014; Death waits for no man - does it wait for a virus? How enteroviruses induce and control cell death. Cytokine Growth Factor Rev 25:587–596 [View Article][PubMed]
    [Google Scholar]
  11. Hay S., Kannourakis G. 2002; A time to kill: viral manipulation of the cell death program. J Gen Virol 83:1547–1564 [View Article][PubMed]
    [Google Scholar]
  12. Hegde S., Rasgon J. L., Hughes G. L. 2015; The microbiome modulates arbovirus transmission in mosquitoes. Curr Opin Virol 15:97–102 [View Article][PubMed]
    [Google Scholar]
  13. Johnson K. N. 2015; The impact of Wolbachia on virus infection in mosquitoes. Viruses 7:5705–5717 [View Article][PubMed]
    [Google Scholar]
  14. Kelly E. M., Moon D. C., Bowers D. F. 2012; Apoptosis in mosquito salivary glands: Sindbis virus-associated and tissue homeostasis. J Gen Virol 93:2419–2424 [View Article][PubMed]
    [Google Scholar]
  15. Liu Q., Clem R. J. 2011; Defining the core apoptosis pathway in the mosquito disease vector Aedes aegypti: the roles of iap1, ark, dronc, and effector caspases. Apoptosis 16:105–113 [View Article][PubMed]
    [Google Scholar]
  16. Liu B., Behura S. K., Clem R. J., Schneemann A., Becnel J., Severson D. W., Zhou L. 2013; P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster . PLoS Pathog 9:e1003137 [View Article][PubMed]
    [Google Scholar]
  17. Means J. C., Passarelli A. L. 2010; Viral fibroblast growth factor, matrix metalloproteases, and caspases are associated with enhancing systemic infection by baculoviruses. Proc Natl Acad Sci U S A 107:9825–9830 [View Article][PubMed]
    [Google Scholar]
  18. Mims C. A., Day M. F., Marshall I. D. 1966; Cytopathic effect of Semliki Forest virus in the mosquito Aedes aegypti . Am J Trop Med Hyg 15:775–784[PubMed]
    [Google Scholar]
  19. Myles K. M., Wiley M. R., Morazzani E. M., Adelman Z. N. 2008; Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoes. Proc Natl Acad Sci U S A 105:19938–19943 [View Article][PubMed]
    [Google Scholar]
  20. O'Neill K., Olson B.J.S.C., Huang N., Unis D., Clem R. J. 2015; Rapid selection against arbovirus-induced apoptosis during infection of a mosquito vector. Proc Natl Acad Sci U S A 112:E1152–E1161 [View Article][PubMed]
    [Google Scholar]
  21. Ocampo C. B., Caicedo P. A., Jaramillo G., Ursic Bedoya R., Baron O., Serrato I. M., Cooper D. M., Lowenberger C. 2013; Differential expression of apoptosis related genes in selected strains of Aedes aegypti with different susceptibilities to dengue virus. PLoS One 8:e61187 [View Article][PubMed]
    [Google Scholar]
  22. Richard A., Tulasne D. 2012; Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis. Cell Death Dis 3:e277 [View Article][PubMed]
    [Google Scholar]
  23. Sim S., Jupatanakul N., Dimopoulos G. 2014; Mosquito immunity against arboviruses. Viruses 6:4479–4504 [View Article][PubMed]
    [Google Scholar]
  24. Tabachnick W. J. 2013; Nature, nurture and evolution of intra-species variation in mosquito arbovirus transmission competence. Int J Environ Res Public Health 10:249–277 [View Article][PubMed]
    [Google Scholar]
  25. Vaidyanathan R., Scott T. W. 2006; Apoptosis in mosquito midgut epithelia associated with West Nile virus infection. Apoptosis 11:1643–1651 [View Article][PubMed]
    [Google Scholar]
  26. Wang H., Blair C. D., Olson K. E., Clem R. J. 2008; Effects of inducing or inhibiting apoptosis on Sindbis virus replication in mosquito cells. J Gen Virol 89:2651–2661 [View Article][PubMed]
    [Google Scholar]
  27. Wang H., Gort T., Boyle D. L., Clem R. J. 2012; Effects of manipulating apoptosis on Sindbis virus infection of Aedes aegypti mosquitoes. J Virol 86:6546–6554 [View Article][PubMed]
    [Google Scholar]
  28. Weaver S. C., Forrester N. L. 2015; Chikungunya: evolutionary history and recent epidemic spread. Antiviral Res 120:32–39 [View Article][PubMed]
    [Google Scholar]
  29. Weaver S. C., Scott T. W., Lorenz L. H., Lerdthusnee K., Romoser W. S. 1988; Togavirus-associated pathologic changes in the midgut of a natural mosquito vector. J Virol 62:2083–2090[PubMed]
    [Google Scholar]
  30. Weaver S. C., Lorenz L. H., Scott T. W. 1992; Pathologic changes in the midgut of Culex tarsalis following infection with Western equine encephalomyelitis virus. Am J Trop Med Hyg 47:691–701[PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/jgv.0.000429
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error