1887

Abstract

Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived dengue virus. Furthermore, in the presence of enhancing antibodies, macrophage-derived virus gave greater enhancement of infection compared with immature DC-derived virus. Taken together, our results highlight the importance of macrophages in dengue infection.

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2016-07-01
2024-03-28
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References

  1. Ayala-Nuñez N. V., Wilschut J., Smit J. M. 2011; Monitoring virus entry into living cells using DiD-labeled dengue virus particles. Methods 55:137–143 [View Article][PubMed]
    [Google Scholar]
  2. Ayala-Nuñez N. V., Jarupathirun P., Kaptein S. J., Neyts J., Smit J. M. 2013; Antibody-dependent enhancement of dengue virus infection is inhibited by SA-17, a doxorubicin derivative. Antiviral Res 100:238–245 [View Article][PubMed]
    [Google Scholar]
  3. Bhatt S., Gething P. W., Brady O. J., Messina J. P., Farlow A. W., Moyes C. L., Drake J. M., Brownstein J. S., Hoen A. G. et al. 2013; The global distribution and burden of dengue. Nature 496:504–507 [View Article]
    [Google Scholar]
  4. Blackley S., Kou Z., Chen H., Quinn M., Rose R. C., Schlesinger J. J., Coppage M., Jin X. 2007; Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in vitro. J Virol 81:13325–13334 [View Article][PubMed]
    [Google Scholar]
  5. Boonnak K., Slike B. M., Burgess T. H., Mason R. M., Wu S. J., Sun P., Porter K., Rudiman I. F., Yuwono D. et al. 2008; Role of dendritic cells in antibody-dependent enhancement of dengue virus infection. J Virol 82:3939–3951 [View Article][PubMed]
    [Google Scholar]
  6. Boonnak K., Dambach K. M., Donofrio G. C., Tassaneetrithep B., Marovich M. A. 2011; Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infection. J Virol 85:1671–1683 [View Article][PubMed]
    [Google Scholar]
  7. Chen S. T., Lin Y. L., Huang M. T., Wu M. F., Cheng S. C., Lei H. Y., Lee C. K., Chiou T. W., Wong C. H. et al. 2008; CLEC5A is critical for dengue-virus-induced lethal disease. Nature 453:672–676 [View Article][PubMed]
    [Google Scholar]
  8. Dejnirattisai W., Webb A. I., Chan V., Jumnainsong A., Davidson A., Mongkolsapaya J., Screaton G. 2011; Lectin switching during dengue virus infection. J Infect Dis 203:1775–1783 [View Article][PubMed]
    [Google Scholar]
  9. Diamond M. S., Roberts T. G., Edgil D., Lu B., Ernst J., Harris E. 2000; Modulation of Dengue virus infection in human cells by alpha, beta, and gamma interferons. J Virol 74:4957–4966 [View Article][PubMed]
    [Google Scholar]
  10. Freigang S., Probst H. C., van den Broek M. 2005; DC infection promotes antiviral CTL priming: the ‘Winkelried' strategy. Trends Immunol 26:13–18 [View Article][PubMed]
    [Google Scholar]
  11. Fuller F. J., Marcus P. I. 1980; Interferon induction by viruses. IV. Sindbis virus: early passage defective-interfering particles induce interferon. J Gen Virol 48:63–73 [View Article][PubMed]
    [Google Scholar]
  12. Halstead S. B. 1979; In vivo enhancement of dengue virus infection in rhesus monkeys by passively transferred antibody. J Infect Dis 140:527–533 [View Article][PubMed]
    [Google Scholar]
  13. Halstead S. B. 1982; Immune enhancement of viral infection. Prog Allergy 31:301–364[PubMed]
    [Google Scholar]
  14. Halstead S. B., Porterfield J. S., O'Rourke E. J. 1980; Enhancement of dengue virus infection in monocytes by flavivirus antisera. Am J Trop Med Hyg 29:638–642[PubMed]
    [Google Scholar]
  15. Honke N., Shaabani N., Cadeddu G., Sorg U. R., Zhang D. E., Trilling M., Klingel K., Sauter M., Kandolf R. et al. 2011; Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol 13:51–57 [View Article][PubMed]
    [Google Scholar]
  16. Huang K. J., Yang Y. C., Lin Y. S., Huang J. H., Liu H. S., Yeh T. M., Chen S. H., Liu C. C., Lei H. Y. 2006; The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J Immunol 176:2825–2832 [View Article][PubMed]
    [Google Scholar]
  17. Jessie K., Fong M. Y., Devi S., Lam S. K., Wong K. T. 2004; Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization. J Infect Dis 189:1411–1418 [View Article][PubMed]
    [Google Scholar]
  18. Kangwanpong D., Bhamarapravati N., Lucia H. L. 1995; Diagnosing dengue virus infection in archived autopsy tissues by means of the in situ PCR method: a case report. Clin Diagn Virol 3:165–172 [View Article][PubMed]
    [Google Scholar]
  19. Li D., Lott W. B., Lowry K., Jones A., Thu H. M., Aaskov J. 2011; Defective interfering viral particles in acute dengue infections. PLoS One 6:e19447 [View Article][PubMed]
    [Google Scholar]
  20. Lyles D., Rupprecht C. 2007; Rhabdoviridae. In Fields Virology pp. 1363–1408 Edited by Knipe D., Howley P. Philadelphia: Lippincot Williams & Wilkins;
    [Google Scholar]
  21. Marovich M., Grouard-Vogel G., Louder M., Eller M., Sun W., Wu S. J., Putvatana R., Murphy G., Tassaneetrithep B. et al. 2001; Human dendritic cells as targets of dengue virus infection. J Investig Dermatol Symp Proc 6:219–224 [View Article][PubMed]
    [Google Scholar]
  22. Miller J. L., de Wet B. J., deWet B. J., Martinez-Pomares L., Radcliffe C. M., Dwek R. A., Rudd P. M., Gordon S. 2008; The mannose receptor mediates dengue virus infection of macrophages. PLoS Pathog 4:e17 [View Article][PubMed]
    [Google Scholar]
  23. Mizumoto K., Ejima K., Yamamoto T., Nishiura H. 2014; On the risk of severe dengue during secondary infection: a systematic review coupled with mathematical modeling. J Vector Borne Dis 51:153–164[PubMed]
    [Google Scholar]
  24. Narvaez F., Gutierrez G., Pérez M. A., Elizondo D., Nuñez A., Balmaseda A., Harris E. 2011; Evaluation of the traditional and revised WHO classifications of Dengue disease severity. PLoS Negl Trop Dis 5:e1397 [View Article][PubMed]
    [Google Scholar]
  25. Ochiai H., Kurokawa M., Hayashi K., Niwayama S. 1988; Antibody-mediated growth of influenza A NWS virus in macrophagelike cell line P388D1. J Virol 62:20–26[PubMed]
    [Google Scholar]
  26. Pham A. M., Langlois R. A., TenOever B. R. 2012; Replication in cells of hematopoietic origin is necessary for Dengue virus dissemination. PLoS Pathog 8:e1002465 [View Article][PubMed]
    [Google Scholar]
  27. Richter M. K., da Silva Voorham J. M., Torres Pedraza S., Hoornweg T. E., van de Pol D. P., Rodenhuis-Zybert I. A., Wilschut J., Smit J. M. 2014; Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN. PLoS One 9:e98785 [View Article][PubMed]
    [Google Scholar]
  28. Russell P. K., Yuill T. M., Nisalak A., Udomsakdi S., Gould D. J., Winter P. E. 1968; An insular outbreak of dengue hemorrhagic fever. II. Virologic and serologic studies. Am J Trop Med Hyg 17:600–608[PubMed]
    [Google Scholar]
  29. Styer L. M., Kent K. A., Albright R. G., Bennett C. J., Kramer L. D., Bernard K. A. 2007; Mosquitoes inoculate high doses of West Nile virus as they probe and feed on live hosts. PLoS Pathog 3:1262–1270 [View Article][PubMed]
    [Google Scholar]
  30. Sun P., Fernandez S., Marovich M. A., Palmer D. R., Celluzzi C. M., Boonnak K., Liang Z., Subramanian H., Porter K. R. et al. 2009; Functional characterization of ex vivo blood myeloid and plasmacytoid dendritic cells after infection with dengue virus. Virology 383:207–215 [View Article][PubMed]
    [Google Scholar]
  31. Sung S. S. 1985; Phagocytosis by mouse peritoneal macrophages plated on monoclonal antibody-coated immune complex-substrates: effects of complexes of different IgG subclasses on Fc receptor functions. J Immunol 135:1981–1986[PubMed]
    [Google Scholar]
  32. van der Schaar H. M., Rust M. J., Waarts B. L., van der Ende-Metselaar H., Kuhn R. J., Wilschut J., Zhuang X., Smit J. M. 2007; Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking. J Virol 81:12019–12028 [View Article][PubMed]
    [Google Scholar]
  33. Wu M. F., Chen S. T., Yang A. H., Lin W. W., Lin Y. L., Chen N. J., Tsai I. S., Li L., Hsieh S. L. 2013; CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood 121:95–106 [View Article][PubMed]
    [Google Scholar]
  34. Wu S. J., Grouard-Vogel G., Sun W., Mascola J. R., Brachtel E., Putvatana R., Louder M. K., Filgueira L., Marovich M. A. et al. 2000; Human skin Langerhans cells are targets of dengue virus infection. Nat Med 6:816–820 [View Article][PubMed]
    [Google Scholar]
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