1887

Abstract

Zika virus (ZIKV) has recently emerged into new areas in the Americas and Asia, causing an epidemic characterized by severe congenital infections. While ZIKV infection is usually asymptomatic or causes mild symptoms, it has now caused a high rate of foetal brain and ocular abnormalities. The underlying reasons for the varying severity of disease outcomes is poorly understood. In this study, we compared the infectivity and replication of three disease-associated Zika viruses of Asian lineage, as well as the prototypic ZIKV strain from Africa. The recent foetal brain isolate FB-GWUH-2016 demonstrated enhanced infectivity and replication over the serum-origin isolates from French Polynesia and Martinique, suggesting differences in the pathogenic properties.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/jgv.0.000857
2017-07-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/98/7/1744.html?itemId=/content/journal/jgv/10.1099/jgv.0.000857&mimeType=html&fmt=ahah

References

  1. Parra B, Lizarazo J, Jiménez-Arango JA, Zea-vera AF, González-Manrique G et al. Guillain-Barré syndrome associated with Zika virus infection in Colombia. N Engl J Med 2016; 375:1513–1523 [View Article][PubMed]
    [Google Scholar]
  2. Krauer F, Riesen M, Reveiz L, Oladapo OT, Martínez-Vega R et al. Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: systematic review. PLoS Med 2017; 14:e1002203 [View Article][PubMed]
    [Google Scholar]
  3. Dick GW, Kitchen SF, Haddow AJ. Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg 1952; 46:509–520 [View Article][PubMed]
    [Google Scholar]
  4. D'Ortenzio E, Matheron S, Yazdanpanah Y, de Lamballerie X, Hubert B et al. Evidence of sexual transmission of Zika virus. N Engl J Med 2016; 374:2195–2198 [View Article][PubMed]
    [Google Scholar]
  5. Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika virus and birth defects-reviewing the evidence for causality. N Engl J Med 2016; 374:1981–1987 [View Article][PubMed]
    [Google Scholar]
  6. Musso D, Gubler DJ. Zika virus. Clin Microbiol Rev 2016; 29:487–524 [View Article][PubMed]
    [Google Scholar]
  7. Driggers RW, Ho CY, Korhonen EM, Kuivanen S, Jääskeläinen AJ et al. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med 2016; 374:2142–2151 [View Article][PubMed]
    [Google Scholar]
  8. Baronti C, Piorkowski G, Charrel RN, Boubis L, Leparc-Goffart I et al. Complete coding sequence of Zika virus from a French polynesia outbreak in 2013. Genome Announc 2014; 2:e00500-14 [View Article][PubMed]
    [Google Scholar]
  9. Piorkowski G, Richard P, Baronti C, Gallian P, Charrel R et al. Complete coding sequence of Zika virus from Martinique outbreak in 2015. New Microbes New Infect 2016; 11:52–53 [View Article][PubMed]
    [Google Scholar]
  10. Chan JF, Yip CC, Tsang JO, Tee KM, Cai JP et al. Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs. Emerg Microbes Infect 2016; 5:e93 [View Article][PubMed]
    [Google Scholar]
  11. Weger-Lucarelli J, Rückert C, Chotiwan N, Nguyen C, Garcia Luna SM et al. Vector competence of American mosquitoes for three strains of Zika virus. PLoS Negl Trop Dis 2016; 10:e0005101 [View Article][PubMed]
    [Google Scholar]
  12. Jääskeläinen J, Kalliomäki P, Paetau A, Timonen T. Effect of LAK cells against three-dimensional tumor tissue. In vitro study using multi-cellular human glioma spheroids as targets. J Immunol 1989; 142:1036–1045[PubMed]
    [Google Scholar]
  13. Simonin Y, Loustalot F, Desmetz C, Foulongne V, Constant O et al. Zika virus strains potentially display different infectious profiles in human neural cells. EBioMedicine 2016; 12:161–169 [View Article][PubMed]
    [Google Scholar]
  14. El Costa H, Gouilly J, Mansuy JM, Chen Q, Levy C et al. ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy. Sci Rep 2016; 6:35296 [View Article][PubMed]
    [Google Scholar]
  15. Grant A, Ponia SS, Tripathi S, Balasubramaniam V, Miorin L et al. Zika virus targets human STAT2 to inhibit type I interferon signaling. Cell Host Microbe 2016; 19:882–890 [View Article][PubMed]
    [Google Scholar]
  16. Kumar A, Hou S, Airo AM, Limonta D, Mancinelli V et al. Zika virus inhibits type-I interferon production and downstream signaling. EMBO Rep 2016; 17:1766–1775 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/jgv.0.000857
Loading
/content/journal/jgv/10.1099/jgv.0.000857
Loading

Data & Media loading...

Supplements

Supplementary File 1

PDF
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error