An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels
Delatorre, Edson and Miranda, Milene and Tschoeke, Diogo A. and Carvalho de Sequeira, Patrícia and Alves Sampaio, Simone and Barbosa-Lima, Giselle and Rangel Vieira, Yasmine and Leomil, Luciana and Bozza, Fernando A. and Cerbino-Neto, José and Bozza, Patricia T. and Ribeiro Nogueira, Rita Maria and Brasil, Patrícia and Thompson, Fabiano L. and de Filippis, Ana M. B. and Souza, Thiago Moreno L.,, 99, 913-916 (2018),
doi = https://doi.org/10.1099/jgv.0.001080,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).,
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